PMID: 6987125Apr 1, 1980Paper

Phenformin increases insulin binding to human cultured breast cancer cells

Diabetes
D CohenP Polosa

Abstract

The effect of the hypoglycemic biguanide, phenformin, on the binding of insulin to MCF-7 cells, an in vitro line derived from a human breast cancer, has been investigated. Cells incubated for 24 h in the presence of 1.0 micrograms/ml of phenformin bound 62.2 +/- 8.1% (mean +/- SE) more 125I-insulin than did controls. The phenformin effect was dose-dependent over the concentration range of 0.1 micrograms/ml to 10.0 micrograms/ml. The increased binding was due to an increase in receptor number without a change in binding affinity. This demonstration of increased receptor number in response to phenformin exposure provides support for the hypothesis that one action of phenformin is to enhance tissue sensitivity to insulin.

Citations

Mar 23, 2002·The American Journal of the Medical Sciences·K GuptaA N Peiris
Nov 1, 1982·Metabolism: Clinical and Experimental·F PurrelloR Vigneri
May 1, 1986·Pharmacological Research Communications·R I Hoich, F M Ng
Apr 1, 1981·Journal of Endocrinological Investigation·Y Iwamoto, I D Goldfine
Dec 1, 1987·Journal of Endocrinological Investigation·K G MountjoyI M Holdaway

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.