Phenobarbital as alternate anticonvulsant for organophosphate-induced benzodiazepine-refractory status epilepticus and neuronal injury

Epilepsia Open
Doodipala Samba ReddyXin Wu

Abstract

Organophosphates (OPs) such as diisopropylfluorophosphate (DFP) and soman are lethal chemical agents that can produce seizures, refractory status epilepticus (SE), and brain damage. There are few optimal treatments for late or refractory SE. Phenobarbital is a second-line drug for SE, usually after lorazepam, diazepam, or midazolam have failed to stop SE. Practically, 40 minutes or less is often necessary for first responders to arrive and assist in a chemical incident. However, it remains unclear whether administration of phenobarbital 40 minutes after OP intoxication is still effective. Here, we investigated the efficacy of phenobarbital treatment at 40 minutes postexposure to OP intoxication. Acute refractory SE was induced in rats by DFP injection as per a standard paradigm. After 40 minutes, subjects were given phenobarbital intramuscularly (30-100 mg/kg) and progression of seizure activity was monitored by video-EEG recording. The extent of brain damage was assessed 3 days after DFP injections by neuropathology analysis of neurodegeneration and neuronal injury by unbiased stereology. Phenobarbital produced a dose-dependent seizure protection. A substantial decrease in SE was evident at 30 and 60 mg/kg, and a complete seiz...Continue Reading

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Dec 1, 1996·The Journal of Physiology·J M RhoM A Rogawski
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·T M Shih, J H McDonough
Dec 21, 2002·Critical Care : the Official Journal of the Critical Care Forum·Elise Whitley, Jonathan Ball
Jul 31, 2003·Epilepsia·Howard P GoodkinGregory L Holmes
Jun 10, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Howard P GoodkinJaideep Kapur
Sep 12, 2006·Journal of the Neurological Sciences·N YanagisawaT Nakajima
Jan 14, 2010·Epilepsia·Marcio de Araujo FurtadoDebra L Yourick
Feb 23, 2010·Annals of Indian Academy of Neurology·Ajith Cherian, Sanjeev V Thomas
May 26, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laxmikant S DeshpandeRobert J DeLorenzo
Jul 6, 2010·Proceedings of the American Thoracic Society·David A Jett, David T Yeung
Aug 4, 2010·Biological Psychiatry·Karl-Anton Dorph-Petersen, David A Lewis
Oct 30, 2010·Toxicologic Pathology·Rogely Waite BoyceHans Jørgen G Gundersen
May 1, 2010·Environmental Toxicology and Pharmacology·Milan Jokanović, Melita Kosanović
Feb 14, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Reza Azizi MalamiriMahmoud Reza Ashrafi
May 15, 2012·Epilepsy Research·Marko S TodorovicJaideep Kapur
Oct 9, 2013·Nature Medicine·Elie Dolgin
Jun 15, 2014·Neurotoxicology·P A FerchminVesna A Eterovic
Aug 27, 2014·The Journal of Pharmacology and Experimental Therapeutics·James P AplandMaria F M Braga
Aug 28, 2015·Drugs·Eugen TrinkaFrancesco Brigo
Nov 20, 2015·Frontiers in Aging Neuroscience·Victoria M GolubDoodipala Samba Reddy
Apr 28, 2016·Journal of Clinical Medicine·Jessica J Falco-Walter, Thomas Bleck
Jul 28, 2016·Annals of the New York Academy of Sciences·Doodipala Samba Reddy
Oct 4, 2016·Therapeutic Advances in Drug Safety·Christopher R NeweyAarti Sarwal
Oct 6, 2016·Critical Reviews in Toxicology·Mohamed B Abou-DoniaAshly Sobel Sokol
Nov 29, 2016·Seizure : the Journal of the British Epilepsy Association·Eugen Trinka, Reetta Kälviäinen
Dec 7, 2016·Statistical Methods in Medical Research·Roland A MatsouakaRebecca A Betensky
Feb 27, 2017·Clinical and Translational Science·D S Reddy, E Colman
Mar 11, 2017·Pharmacology & Therapeutics·Iyan Younus, Doodipala Samba Reddy
Mar 23, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brad A HobsonPamela J Lein
Mar 23, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sílvia SisóPamela J Lein
Apr 26, 2018·The New England Journal of Medicine·Gregory R Ciottone
May 29, 2018·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ramkumar KurubaDoodipala Samba Reddy

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