PMID: 3384091Jun 6, 1988Paper

Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells

FEBS Letters
L Corcos, M C Weiss

Abstract

Hepatoma cells derived from the Reuber H35 rat hepatoma express cytochrome P450 enzymes of two major families: polycyclic aromatic hydrocarbon-inducible forms are found in both differentiated and dedifferentiated cells while phenobarbital (PB)-inducible forms are found only in differentiated cells. We report here that (i) benzanthracene and PB induce P450 c mRNA in differentiated and dedifferentiated cells and (ii) dexamethasone and PB induce P450 b/e and/or P450 PB1 mRNAs in differentiated cells but not in dedifferentiated cells.

References

Jan 1, 1986·CRC Critical Reviews in Biochemistry·M Adesnik, M Atchison
Mar 15, 1984·Biochemical Pharmacology·D W NebertO Hankinson
Aug 1, 1984·Journal of Cellular Physiology·A B FreyG Kreibich
May 30, 1980·Biochemical and Biophysical Research Communications·F J WiebelM Lambiotte

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Citations

Sep 25, 2002·The Journal of Biological Chemistry·Arlette MoncionIsabelle De Waziers
Jul 1, 1990·Molecular & General Genetics : MGG·L CorcosM C Weiss
May 21, 1999·Drug Metabolism Reviews·U A Meyer, K Hoffmann
Jul 27, 2006·Expert Opinion on Drug Metabolism & Toxicology·José V CastellMaría José Gómez-Lechón
Oct 15, 1990·Biochemical Pharmacology·S Chasserot-GolazL Corcos
Apr 1, 1993·The International Journal of Biochemistry·M A Lea
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·S Chasserot-Golaz, G Beck
Jan 1, 1989·Journal of Steroid Biochemistry·S Chasserot-GolazG Beck

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