Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae

Journal of Natural Products
Ik-Soo LeeJin Sook Kim

Abstract

Three new phenolic biphenyl derivatives (1-3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1-4 on rat lens aldose reductase in vitro were examined, and compounds 1-3 markedly inhibited the enzyme with IC50 values of 3.8 to 13.8 μM. In addition, the effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in zebrafish larvae were investigated. Compound 1 was the most effective in reducing HG-induced dilation of hyaloid-retinal vessels.

References

Jun 20, 1975·Science·S D VarmaJ H Kinoshita
Jun 1, 1990·Experimental Eye Research·J H Kinoshita
Dec 1, 1972·The Journal of Clinical Investigation·A D MorrisonA I Winegrad
Dec 1, 1982·Biochemical Pharmacology·J OkudaM Nakayama
Jun 5, 2002·Chemical & Pharmaceutical Bulletin·Hisashi MatsudaMasayuki Yoshikawa
Aug 30, 2005·Journal of Natural Products·Vatcharin RukachaisirikulSouwalak Phongpaichit
Jul 29, 2006·Journal of Natural Products·Yi DaiXin-sheng Yao
Feb 3, 2007·Chemical & Pharmaceutical Bulletin·Hirotsugu YamauchiMasao Kikuchi
Mar 10, 2012·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K JörgensJ Kroll

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.