Phenolic constituents from Rhopalocnemis phalloides with DPPH radical scavenging activity

Pharmaceutical Biology
Gai-Mei SheChong-Ren Yang

Abstract

The 80% aqueous acetone extract of the whole plant of Rhopalocnemis phalloides Jungh. (Balanophoraceae) showed obvious radical scavenging activity (SC(50) = 32.1 mug/mL) on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay. Further chemical investigation of the extract led to the isolation of 12 phenolic compounds (1-12). Among these, bis-6,8'-catechinylmethane (2), a flavan-3-ol dimer, was first isolated as a natural product from Rhopalocnemis phalloides. The full NMR assignments of bis-catechinylmethanes (1 and 2) are reported for the first time, on the basis of detailed spectroscopic analysis. The DPPH assay showed that flavan-3-ol dimers (1-3) had remarkable free radical scavenging activity, while flavonoid aglycones (4 and 9) presented stronger activities than those of their glycosides (5-8 and 10).

References

Feb 1, 1979·Journal of Pharmaceutical Sciences·M M ChienJ E Knapp
Mar 1, 1996·Diabetes Care·D GiuglianoG Paolisso
Jul 18, 2001·Chemical & Pharmaceutical Bulletin·Z H JiangI Kouno
May 17, 2005·Journal of Ethnopharmacology·Kai-Jin WangChong-Ren Yang
Jul 11, 2006·Journal of Neuropathology and Experimental Neurology·Akihiko NunomuraMark A Smith
Oct 10, 2006·Trends in Molecular Medicine·A Wood-KaczmarN W Wood
Dec 29, 2006·Chemistry & Biodiversity·Kai-Jin WangChong-Ren Yang
Oct 6, 2007·Planta medica·Xian-Wen YangXiao-Jiang Hao
Jan 29, 2008·Recent Patents on Cardiovascular Drug Discovery·Reiko Inagi

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Citations

Aug 3, 2012·Chemistry Central Journal·Xiaohong WangGaimei She
Dec 21, 2011·Pharmaceutical Biology·Yassir Mohammed AliMuhammed Nazrul Hakim Abdullah
Jan 24, 2014·Journal of Agricultural and Food Chemistry·Qing MaXiaoyi Wei

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