Phenolic-rich extracts of Eurycoma longifolia and Cylicodiscus gabunensis inhibit enzymes responsible for the development of erectile dysfunction and are antioxidants

Journal of Basic and Clinical Physiology and Pharmacology
Ganiyu ObohAyokunle O Ademosun

Abstract

Herbs have been used from ages to manage male sexual dysfunction. Hence, this study sought to investigate the effects of Eurycoma longifolia (EL) and Cylicodiscus gabunensis (CG) stem bark extracts on some enzymes implicated in erectile dysfunction in vitro. The extracts were prepared, and their effects on phosphodiesterase-5 (PDE-5), arginase, and angiotensin-1-converting enzyme (ACE) as well as pro-oxidant-induced lipid peroxidation were assessed. Furthermore, phenolic contents were determined, and their components were characterized and quantified using high-performance liquid chromatography with diode array detector (HPLC-DAD). The results revealed that the extracts inhibited PDE-5, arginase, and ACE in a concentration-dependent manner. However, IC50 values revealed that CG had higher inhibitory potential on PDE-5 (IC50=204.4 μg/mL), arginase (IC50=39.01 μg/mL), and ACE (IC50=48.81 μg/mL) than EL. In addition, the extracts inhibited pro-oxidant-induced lipid peroxidation in penile tissue homogenate. HPLC-DAD analysis showed that CG is richer in phenolic compounds than EL, and this could be responsible for higher biological activities observed in CG than EL. Hence, the observed antioxidant property and inhibitory action of C...Continue Reading

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Citations

Aug 31, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Ganiyu ObohAyokunle O Ademosun
Jul 26, 2019·BMC Complementary and Alternative Medicine·Omar AldulaimiWen-Wu Li
Nov 3, 2020·Journal of Ethnopharmacology·A Anand GanapathyAlaganandam Kumaran
Dec 6, 2020·Sexual Medicine Reviews·Valerie Jia-En SinHwee-Ling Koh

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