Phenome-Wide Association Studies Uncover a Novel Association of Increased Atrial Fibrillation in Male Patients With Systemic Lupus Erythematosus

Arthritis Care & Research
April BarnadoLeslie J Crofford

Abstract

Phenome-wide association studies (PheWAS) scan across billing codes in the electronic health record (EHR) and re-purpose clinical EHR data for research. In this study, we examined whether PheWAS could function as an EHR-based discovery tool for systemic lupus erythematosus (SLE) and identified novel clinical associations in male versus female patients with SLE. We used a de-identified version of the Vanderbilt University Medical Center EHR, which includes more than 2.8 million subjects. We performed EHR-based PheWAS to compare SLE patients with age-, sex-, and race-matched control subjects and to compare male SLE patients with female SLE patients, controlling for multiple testing using a false discovery rate (FDR) P value of 0.05. We identified 1,097 patients with SLE and 5,735 matched control subjects. In a comparison of patients with SLE and matched controls, SLE patients were shown to be more likely to have International Classification of Diseases, Ninth Revision codes related to the SLE disease criteria. In the PheWAS of male versus female SLE patients, with adjustment for age and race, male patients were shown to be more likely to have atrial fibrillation (odds ratio 4.50, false discovery rate P = 3.23 × 10-3 ). Chart revi...Continue Reading

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Citations

Feb 27, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Monika GawałkoJędrzej Kosiuk
May 22, 2020·Digestive Diseases and Sciences·Winston CaiAshwin N Ananthakrishnan
May 29, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ashutossh NaaraayanPrakash Acharya
Nov 4, 2021·Nature Reviews. Rheumatology·Kathryn M KingsmorePeter E Lipsky

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