Phenomenologic model describing flow reduction for parotid gland irradiation with intensity-modulated radiotherapy: evidence of significant recovery effect

International Journal of Radiation Oncology, Biology, Physics
Rufus ScrimgerB Gino Fallone

Abstract

To develop a model describing the relationship between the parotid gland radiation dose and salivary flow reduction. Salivary function was described by the "relative flow reduction" (RFR)-a continuous variable in contrast to the traditional binary response used in normal tissue complication probability estimations. Twenty-three patients with squamous cell carcinoma of the head and neck who were treated with intensity-modulated radiotherapy (RT) were the subject of this study. Of these patients, 19 had sufficiently long follow-up to be eligible for analysis. All were treated with curative intent, most (14 of 19) in the postoperative setting. The planning objectives were to deliver a mean dose of 50, 60, or 70 Gy, respectively, to low-risk microscopic, high-risk microscopic, and gross disease areas, while maintaining a mean dose of < or =20 Gy to the spared portion of one or both parotid glands. The mean dose to all parotid glands (right and left) was 30.2 Gy. All submandibular glands received >50 Gy when not surgically removed. Whole-mouth saliva collections, including both stimulated and unstimulated saliva flow, were obtained before treatment and at regular intervals after RT. These measurements were converted to the RFR by co...Continue Reading

References

Jul 1, 1992·Medical Physics·R MohanZ Fuks
Jan 5, 2002·International Journal of Radiation Oncology, Biology, Physics·Qiuwen WuRupert Schmidt-Ullrich

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Citations

Jun 1, 2005·International Journal of Radiation Oncology, Biology, Physics·Marco van VulpenB Gino Fallone
Apr 9, 2005·Current Opinion in Oncology·Theodore S HongPaul M Harari
Sep 8, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Martin Scott-BrownChris Nutting
Jul 9, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C OrtholanR-J Bensadoun
Sep 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Pètra M BraamCornelis P J Raaijmakers
Mar 31, 2010·International Journal of Radiation Oncology, Biology, Physics·Marciana Nona DumaHans Geinitz
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael K M KamAnthony T C Chan
Sep 21, 2011·Expert Review of Anticancer Therapy·Rufus Scrimger

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