Phenomenological model and phase behavior of saturated and unsaturated lipids and cholesterol.

Biophysical Journal
G Garbès Putzel, M Schick

Abstract

We present a phenomenological theory for the phase behavior of ternary mixtures of cholesterol and saturated and unsaturated lipids, one that describes both liquid and gel phases. It leads to the following description of the mechanism of the phase behavior: In a binary system of the lipids, phase separation occurs when the saturated chains are well ordered, as in the gel phase, simply due to packing effects. In the liquid phase, the saturated ones are not sufficiently well ordered for separation to occur. The addition of cholesterol, however, increases the saturated lipid order to the point that phase separation is once again favorable. Our theory addresses this last mechanism-the means by which cholesterol-mediated ordering of membrane lipids leads to liquid-liquid immiscibility. It produces, for the system above the main chain transition of the saturated lipid, phase diagrams in which there can be liquid-liquid phase separation in the ternary system but not in any of the binary ones, while below that temperature it yields the more common phase diagram in which a gel phase, rich in saturated lipid, appears in addition to the two liquid phases.

References

Oct 19, 1978·Biochimica Et Biophysica Acta·T J McIntosh
Nov 27, 1987·Biochimica Et Biophysica Acta·J H IpsenM J Zuckermann
Mar 17, 1971·Nature: New Biology·Y K Levine, M H Wilkins
Feb 27, 2001·Biophysical Journal·C DietrichE Gratton
Dec 18, 2002·Physical Review Letters·Sarah L Veatch, Sarah L Keller
Jan 14, 2003·Biophysical Journal·Sarah L Veatch, Sarah L Keller
Jan 25, 2003·Annual Review of Biophysics and Biomolecular Structure·Michael Edidin
Nov 19, 2003·Cell·Sean Munro
Mar 3, 2004·Biophysical Journal·Sagar A PanditMax L Berkowitz
Apr 28, 2004·Biophysical Journal·S L VeatchS L Keller
May 21, 2005·Physical Review Letters·Sarah L Veatch, Sarah L Keller
Jun 14, 2005·Biophysical Journal·Mary Elizabeth BeattieSarah L Keller
Jul 27, 2005·Biochimica Et Biophysica Acta·Sarah L Veatch, Sarah L Keller
Aug 6, 2005·The Journal of Chemical Physics·George A KhelashviliH L Scott
Aug 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Arun Radhakrishnan, Harden McConnell
Jan 5, 2006·Journal of the American Chemical Society·Chiara NicoliniRoland Winter
Apr 21, 2006·Nature Reviews. Molecular Cell Biology·John F Hancock
Oct 31, 2006·Biophysical Journal·Sagar A PanditH L Scott
Mar 21, 2007·Biophysical Journal·Wei-Chin HungHuey W Huang
Oct 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sarah L VeatchKlaus Gawrisch
Nov 13, 2007·Biophysical Journal·Artem G Ayuyan, Fredric S Cohen
Mar 15, 2008·Biophysical Journal·Smita P SoniStephen R Wassall
Apr 22, 2008·Biophysical Journal·Aurelia R Honerkamp-SmithSarah L Keller

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Citations

Oct 22, 2009·European Biophysics Journal : EBJ·Luís M S LouraManuel Prieto
Sep 22, 2012·Journal of the American Chemical Society·Zhenlong LiAlemayehu A Gorfe
Jan 29, 2011·The Journal of Physical Chemistry. B·Jian DaiJuyang Huang
Oct 26, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Pradeep UppamoochikkalJohn F Nagle
Feb 16, 2010·The Journal of Chemical Physics·Paul W TumanengH L Scott
Aug 12, 2014·The Journal of Chemical Physics·Md Kabir Uddin SikderMohamed Laradji
Oct 22, 2008·Biochimica Et Biophysica Acta·Aurelia R Honerkamp-SmithSarah L Keller
Sep 1, 2012·Small GTPases·Zhenlong Li, Alemayehu A Gorfe
Aug 19, 2009·Biophysical Journal·R BrewsterS A Safran
May 5, 2016·The Journal of Physical Chemistry. B·Naofumi ShimokawaDavid Andelman
Jun 8, 2011·The Journal of Physical Chemistry. B·Michael J SkaugRoland Faller
Mar 28, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Benoit Palmieri, Samuel A Safran
May 12, 2017·Physical Chemistry Chemical Physics : PCCP·Naofumi ShimokawaMasahiro Takagi
Jan 21, 2014·Advances in Colloid and Interface Science·Shigeyuki Komura, David Andelman
Jun 29, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·G Garbès Putzel, M Schick
Feb 17, 2017·The Journal of Chemical Physics·Davit Hakobyan, Andreas Heuer
Nov 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·T IdemaC Storm
Apr 27, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Paul W TumanengH L Scott
Nov 9, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Naofumi ShimokawaDavid Andelman
Nov 17, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Alysha MorettiKathryn E Uhrich
Mar 17, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Nichaporn WongsirojkulTsutomu Hamada

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