PMID: 8584680Oct 1, 1995Paper

Phenomenology and neurobiology of cocaine withdrawal: are they related?

Progress in Neuro-psychopharmacology & Biological Psychiatry
A PathirajaR L Borison

Abstract

1. The presence of mood disturbances and platelet 3H-imipramine binding, a putative peripheral serotonergic marker, were evaluated in a group of 27 cocaine users three days after drug withdrawal. 2. Parameters of cocaine use and the linkage between cocaine withdrawal and "post-cocaine depression" were also investigated. In a subgroup of 10 patients, both psychopathological and biological measurements were repeated after 5 or 6 weeks. 3. Interpretation of the data by Pearson's analysis showed a statistically significant and positive correlation between Hamilton Rating Scale for Depression (HAM-D) scores and period of use. A trend towards a negative correlation, which however did not reach the statistical significance, was found between 3H-Imipramine binding and period of cocaine use, number of days of abstinence and HAM-D scores 4. When compared with normal volunteers at baseline, patients had significantly lower Bmax and Kd values which returned towards normal values after 5 or 6 weeks of cocaine withdrawal. 5. These results indicate the presence of a decreased platelet imipramine binding during cocaine withdrawal which may be due to the effect of the drug or alternatively, a result of concomitant depression which may be primar...Continue Reading

References

Jan 1, 1977·Journal of Neuroscience Research·D Taylor, B T Ho
Oct 1, 1979·European Journal of Pharmacology·M S BrileyS Z Langer
Jul 1, 1989·Psychiatry Research·A E TheodorouE S Paykel
Jan 1, 1989·Comprehensive Psychiatry·M H PollackJ F Rosenbaum
Nov 4, 1988·Science·G F Koob, F E Bloom
May 5, 1988·The New England Journal of Medicine·F H Gawin, E H Ellinwood
Jun 1, 1986·The American Journal of Psychiatry·M BaronF Quitkin
Feb 1, 1986·Archives of General Psychiatry·F H Gawin, H D Kleber
Nov 1, 1985·Biological Psychiatry·B E Suranyi-CadotteR Quirion
Nov 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·F H Gawin, H D Kleber

❮ Previous
Next ❯

Citations

Apr 24, 2007·Neurotoxicity Research·Neil E Paterson, Athina Markou
May 17, 2005·Neuroscience and Biobehavioral Reviews·Alasdair M Barr, Athina Markou
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Alasdair M Barr, Anthony G Phillips
Nov 5, 1999·Pharmacology, Biochemistry, and Behavior·A M BarrA G Phillips
Jul 1, 2008·Drug and Alcohol Dependence·Kenneth R ConnerAmanda P Holbrook
Jun 1, 2015·Journal of Psychiatric Research·Gabriel R FriesMaria Luiza Saraiva-Pereira
Jan 16, 2020·Current Pharmaceutical Design·Branka PetkovićVesna Pešić

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.