Phenotype and natural killer cell sensitivity of a radiation-induced acute T-cell leukaemia (Roser leukaemia) in PVG rats

Scandinavian Journal of Immunology
J NestvoldB Rolstad

Abstract

A radiation-induced T-cell leukaemia [Roser leukaemia (RL)] in the rat was conditioned for growth in vitro by repeated in vivo-in vitro passages. This in vitro cell line, termed RL-T, maintained its leukaemia-inducing property when transferred to syngeneic PVG rats. It expresses several T-cell markers and the T-cell alpha/beta receptor-CD3 complex. RL-T, furthermore, expresses major histocompatibility complex (MHC) I antigens, both classical (RT1.A) and nonclassical (RT1.C), which makes it susceptible to killing by alloreactive natural killer cells in vitro.

References

Jul 1, 1975·Pathology·M DibleyB Roser
Jan 1, 1983·Immunological Reviews·D W MasonM L Thomas
Nov 1, 1984·British Journal of Cancer·H JacksonM Lendon
Apr 1, 1980·The Biochemical Journal·D W Mason, A F Williams
Nov 28, 2000·European Journal of Immunology·G LøvikB Rolstad
Aug 22, 2001·Immunological Reviews·B RolstadG W Butcher
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian NaperJames C Ryan
Jun 28, 2002·Immunological Reviews·T K van den BergC D Dijkstra
Jul 13, 2002·European Journal of Immunology·Christian NaperJames C Ryan

❮ Previous
Next ❯

Citations

Nov 29, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Mi HouKirsi Jahnukainen
Oct 6, 2007·International Journal of Andrology·Mi HouKirsi Jahnukainen
Jun 3, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Per O IversenChristian A Drevon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.