Phenotype of mice with inducible ablation of GluA1 AMPA receptors during late adolescence: relevance for mental disorders

Hippocampus
Dragos IntaPeter Gass

Abstract

Adolescence is characterized by important molecular and anatomical changes with relevance for the maturation of brain circuitry and cognitive function. This time period is of critical importance in the emergence of several neuropsychiatric disorders accompanied by cognitive impairment, such as affective disorders and schizophrenia. The molecular mechanisms underlying these changes at neuronal level during this specific developmental stage remains however poorly understood. GluA1-containing AMPA receptors, which are located predominantly on hippocampal neurons, are the primary molecular determinants of synaptic plasticity. We investigated here the consequences of the inducible deletion of GluA1 AMPA receptors in glutamatergic neurons during late adolescence. We generated mutant mice with a tamoxifen-inducible deletion of GluA1 under the control of the CamKII promoter for temporally and spatially restricted gene manipulation. GluA1 ablation during late adolescence induced cognitive impairments, but also marked hyperlocomotion and sensorimotor gating deficits. Unlike the global genetic deletion of GluA1, inducible GluA1 ablation during late adolescence resulted in normal sociability. Deletion of GluA1 induced redistribution of Glu...Continue Reading

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Citations

Jun 5, 2014·European Archives of Psychiatry and Clinical Neuroscience·Miriam A VogtDragos Inta
Jan 24, 2015·Neuroscience and Biobehavioral Reviews·Colm M O'Tuathaigh, John L Waddington
Dec 17, 2014·Frontiers in Synaptic Neuroscience·Gregg W Crabtree, Joseph A Gogos
Jul 16, 2016·Neurobiology of Learning and Memory·Florian FreudenbergPeter H Seeburg
Sep 2, 2016·European Archives of Psychiatry and Clinical Neuroscience·Alessia LuoniDragos Inta
Nov 1, 2016·Molecular Neurobiology·Lucia CaffinoFabio Fumagalli
Apr 1, 2017·European Archives of Psychiatry and Clinical Neuroscience·Rainer WolfHerbert Schwegler
Dec 31, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tillmann WeberPeter Gass
Sep 11, 2016·Neuroscience of Consciousness·W A PhillipsS M Silverstein
Mar 3, 2020·Frontiers in Neurology·Maria Pia GiannoccaroAngela Vincent

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