Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study

The European Respiratory Journal
Vladimir KoblizekArschang Valipour

Abstract

Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries; however, there are no data regarding clinical phenotypes of these patients in this region.Participation in the Phenotypes of COPD in Central and Eastern Europe (POPE) study was offered to stable patients with COPD in a real-life setting. The primary aim of this study was to assess the prevalence of phenotypes according to predefined criteria. Secondary aims included analysis of differences in symptom load, comorbidities and pharmacological treatment.3362 patients with COPD were recruited in 10 CEE countries. 63% of the population were nonexacerbators, 20.4% frequent exacerbators with chronic bronchitis, 9.5% frequent exacerbators without chronic bronchitis and 6.9% were classified as asthma-COPD overlap. Differences in the distribution of phenotypes between countries were observed, with the highest heterogeneity observed in the nonexacerbator cohort and the lowest heterogeneity observed in the asthma-COPD cohort. There were statistically significant differences in symptom load, lung function, comorbidities and treatment between these phenotypes.The majority of patients with stable COPD in CEE are nonex...Continue Reading

References

Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease
Jun 5, 2010·American Journal of Respiratory and Critical Care Medicine·MeiLan K HanFernando J Martinez
Sep 14, 2010·Respiratory Research·Alvar AgustiUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
Oct 12, 2010·American Journal of Respiratory and Critical Care Medicine·Roberto de MarcoUNKNOWN European Community Respiratory Health Survey (ECRHS)
Apr 7, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Gregory D SalinasJill A Foster
Sep 29, 2011·Respiratory Research·Megan HardinUNKNOWN COPDGene Investigators
Apr 10, 2012·Respiratory Medicine·Antonio Corrado, Andrea Rossi
Apr 24, 2012·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Marc MiravitllesEsther Anton
Jun 5, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vladimir KoblizekUNKNOWN Czech Pneumological and Phthisiological Society
Feb 21, 2014·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboUNKNOWN Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study Investigators
May 31, 2014·The European Respiratory Journal·Megan HardinCraig P Hersh
Dec 23, 2014·Respiratory Medicine·Anne LindbergEva Rönmark
Jan 2, 2015·The European Respiratory Journal·Lowie E G W Vanfleteren
Jul 15, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M MiravitllesM Román-Rodríguez
Jan 23, 2016·The European Respiratory Journal·Marc MiravitllesFrancesco Blasi
Mar 8, 2016·American Journal of Respiratory and Critical Care Medicine·Teresa ToUNKNOWN Canadian Respiratory Research Network
Mar 15, 2016·Annals of the American Thoracic Society·Suchit KumbhareCharlie Strange
Jun 25, 2016·The European Respiratory Journal·Don D SinMichael E Wechsler

❮ Previous
Next ❯

Citations

Oct 13, 2018·Expert Opinion on Pharmacotherapy·Andrea S Melani
May 13, 2017·The European Respiratory Journal·Yingmeng Ni, Guochao Shi
Nov 2, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Joseph Emil AmegadzieZhiwei Gao
May 26, 2018·Wiener klinische Wochenschrift·Gabriele ReigerArschang Valipour
Jul 14, 2019·BMC Pulmonary Medicine·Laurie PahusUNKNOWN Initiatives BPCO scientific committee
May 2, 2020·Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury·T N ZaripovaG G Reshetova
Aug 8, 2020·American Journal of Respiratory and Critical Care Medicine·Samy Suissa
Oct 3, 2020·Archivos de bronconeumología·Mònica MonteagudoMarc Miravitlles
Mar 25, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Zorica LazicVojislav Cupurdija
Jun 4, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Natalia Celejewska-WójcikKrzysztof Sładek
May 21, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Ioanna TsiligianniRudi Peché
Jun 26, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Marc MiravitllesGerard Urrútia
Jun 25, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Miguel Roman-Rodriguez, Alan Kaplan
Jul 24, 2021·Breathe·Vincent BrennanRichard W Costello

❮ Previous
Next ❯

Software Mentioned

COPDGene
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved