PMID: 8599880Jan 1, 1996Paper

Phenotypic abnormalities of splenic and bone marrow B cells in lpr and gld mice

Clinical Immunology and Immunopathology
E A ReapR A Eisenberg

Abstract

Mice homozygous for the mutant Fas gene lpr develop generalized lymphoproliferation and produce autoantibodies resembling those found in human SLE. We have previously shown that these autoantibodies are produced by B2 cells rather than B1 cells and that the autoantibody- producing B cells are intrinsically abnormal. We investigated further the lpr B cell with a large panel of antibodies to B-cell surface markers to identify phenotypic abnormalities. B cells from spleen and bone marrow of age-matched congenic mice differing only at the lpr locus were examined by flow cytometry. Two consistent phenotypic differences were identified. First, spleen cells from older lpr mice had an increase in the number and percentage of IgM+ B cells expressing low levels of CD23. Second, lpr bone marrow had decreased numbers of B220hiIgM+-syndecan-1+CD23+ B cells. All other markers tested, except the previously identified modest increase of Ia on lpr spleen cells, showed no consistent differences. B cells from gld mice showed the same phenotypic abnormalities as those from lpr. Compared to T cells, the relative paucity of cell surface marker differences between lpr and +/+ B cells suggests that B cells may have fewer regulatory mechanisms to silen...Continue Reading

Citations

Jun 10, 1998·The Journal of Experimental Medicine·W F DavidsonT N Fredrickson
Dec 8, 2004·The Journal of Experimental Medicine·Jian Qiao ZhangWendy F Davidson
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·E A ReapP L Cohen
Jul 24, 2008·Clinical and Experimental Immunology·S TachikawaT Abo
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Debora R SekiguchiRobert A Eisenberg
Aug 30, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yumi NakayamaGarth E Ringheim
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vedran KatavićAna Marusić

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