Phenotypic alteration of interstitial cells of Cajal in idiopathic sigmoid megacolon.

Journal of Gastroenterology
Yasushi AdachiYasuo Kato

Abstract

Interstitial cells of Cajal (ICCs) are detected as a pacemaker of gastrointestinal movement and express c-kit and CD34. Recently, ICCs have implicated pathogenesis in several human diseases presenting gastrointestinal motor dysfunction. This study was performed to clarify the role of ICCs in idiopathic sigmoid megacolon using histological and immunohistochemical examinations. Four adult patients with idiopathic sigmoid megacolon and 11 controls were studied. Histology and immunocytochemistry using NSE, S100, c-kit, and CD34 were performed in conjunction with quantitative analysis using the public domain NIH image program. Little histological change in neuromuscular structures in megacolon was observed. Immunohistochemistry demonstrated remarkable decrease of c-kit expressing ICCs without reduction of CD34 expression in the similar interstitial cell population. This observation was further supported by quantitative assessment using public domain NIH image program. A specific downregulation of c-kit in ICCs may be a cause of idiopathic sigmoid megacolon in adults.

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Citations

Jan 18, 2014·Cell and Tissue Research·Jia WeiJiexiong Feng
Jul 26, 2014·Histochemistry and Cell Biology·Samir JabariAlexandre B M da Silveira
Feb 24, 2009·Acta histochemica·Nilce Mitiko MatsudaJoseph H Szurszewski
Jul 3, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S JabariA Brehmer
Aug 19, 2020·The Journal of Clinical Investigation·Xuyong ChenJiexiong Feng

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