Phenotypic analysis of mice xenografted with canine epitheliotropic cutaneous T-cell lymphoma cells

Veterinary Dermatology
Miho IkeuchiSadatoshi Maeda

Abstract

In canine epitheliotropic cutaneous T-cell lymphoma (ECTCL), neoplastic cells cause skin lesions and potentially metastasize to lymph nodes, blood and other organs. Murine models are potentially valuable for elucidating the molecular mechanisms responsible for regulation of ECTCL cell migration. To describe a phenotype of mice xenografted with canine ECTCL cells (EO-1 cells). Four NOD.CB17-Prkdcscid /J (NOD SCID) mice were used. EO-1 cells were subcutaneously xenografted into NOD SCID mice. After four weeks, the development of tumour lesions in skin and other organs was investigated. Mice developed skin lesions with metastasis to the lymph nodes, spleen, lung, blood and liver. Mice xenografted with EO-1 cells may be useful for studying the pathogenesis of canine ECTCL.

References

Feb 5, 2002·Immunity·Eric J Kunkel, Eugene C Butcher
Dec 18, 2002·The Journal of Investigative Dermatology·Katalin FerencziThomas S Kupper
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S MaedaH Tsujimoto
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·James J CampbellMarc-André Wurbel
Oct 9, 2008·The Journal of Veterinary Medical Science·Nobutaka YasudaSadatoshi Maeda
Feb 19, 2009·Veterinary and Comparative Oncology·J FontaineR S Mueller
Feb 26, 2009·The Kaohsiung Journal of Medical Sciences·Chieh-Shan WuMeng-Tse Wu
Feb 10, 2010·Veterinary Dermatology·Jacques FontaineMichael J Day
Feb 13, 2010·Journal of Experimental & Clinical Cancer Research : CR·Udo Doebbeling
Jul 16, 2010·Experimental Dermatology·Thorbjørn KrejsgaardAnders Woetmann
Sep 29, 2011·Veterinary Immunology and Immunopathology·Naoki ChimuraSadatoshi Maeda
Dec 1, 2012·The Journal of Veterinary Medical Science·Saori UmekiTakuya Mizuno
Mar 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michinori OguraRyuzo Ueda
Jun 2, 2016·Therapeutic Advances in Hematology·Madeleine DuvicCasey Wang
Jul 6, 2016·The British Journal of Dermatology·M BattistellaA Janin
Feb 14, 2017·Journal of Toxicologic Pathology·Satoshi FurukawaKiyokazu Ozaki
Jul 3, 2017·Journal of Dermatological Science·Kyohei HaraSadatoshi Maeda

❮ Previous
Next ❯

Citations

Dec 7, 2021·The Journal of Veterinary Medical Science·Toshitaka KaneiSadatoshi Maeda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.