Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia

Leukemia & Lymphoma
A GagroB Vitale

Abstract

Whole-blood three-color immunofluorescence analysis was used to investigate the role of CD5/CD72 and CD21/CD23 receptor-ligand pair formation on B-chronic lymphocytic leukemia (B-CLL) cells as well as sCD23 and bcl-2 oncoprotein expression in disease progression and activity and total tumor mass in B-cell chronic leukemia (B-CLL) patients. Thirty-four patients with B-CLL and 19 controls were included in the study. The majority of B-cells in B-CLL patients coexpressed CD5 and CD72 as well as the CD23 antigen. Unlike B-cells in B-CLL patients, B-cells in all healthy controls tested had high expression of CD21 antigen. We identified two groups of B-CLL patients according to high (n = 20) or low levels (n = 14) of CD21 expression on CD19+CD23+ B-cells. Only in the patients with high CD21 expression, were sCD23 levels positively correlated with factors known to have prognostic significance in B-CLL (Rai stage and TTM) and could, therefore, be used as a prognostic parameter for these B-CLL patients. Bcl-2 oncoprotein expression did not differ between these patient groups. We presumed that in patients with a lower expression of CD21 antigen, the contribution of the CD21 molecule to homotypic adhesion was lacking. Further studies are n...Continue Reading

References

Feb 1, 1992·Immunological Reviews·G DelespesseM Letellier
Aug 6, 1992·Nature·J P AubryJ Y Bonnefoy
May 1, 1992·British Journal of Haematology·A S KurecF R Davey
Jan 1, 1991·Advances in Immunology·G DelespesseA Dalloul
Jun 20, 1991·Nature·H Van de VeldeK Thielemans
Nov 1, 1981·British Journal of Haematology·B Jaksić, B Vitale
Apr 1, 1993·Current Opinion in Immunology·P D Burrows, M D Cooper
Oct 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W ReinischG Boltz-Nitulescu
Sep 1, 1994·Immunology Today·J Gordon
Mar 1, 1994·American Journal of Clinical Pathology·T E WitzigJ A Katzmann
Nov 1, 1993·Clinical and Experimental Immunology·S RabatićM Medar-Lasić
Aug 1, 1993·European Journal of Immunology·P BjörckS Paulie

❮ Previous
Next ❯

Citations

Apr 8, 1999·Leukemia & Lymphoma·A CrielC De Wolf-Peeters
Nov 26, 2003·Scandinavian Journal of Immunology·B VitaleB Jaksić
Jun 25, 2004·American Journal of Reproductive Immunology : AJRI·Emilia JureticMladen Petrovecki

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.