PMID: 6982904Oct 1, 1982Paper

Phenotypic and functional characterization of a Sézary cell

Journal of Clinical Immunology
S RomagnaniM Ricci

Abstract

We have studied the surface antigen pattern, enzymatic phenotype, and functional capacity of peripheral blood lymphocytes from a patient with Sézary syndrome (SS). The majority of these cells formed E rosettes but lacked the Fc(mu) receptor. The neoplastic cells were reactive with pan-T cell (OKT3)- and helper T cell (OKT4)-subset monoclonal antibodies; however, they lacked the 5/9 antigen, which identifies a more restricted subset of helper T cells. Most SS cells also reacted with PTF 29.12, a monoclonal antibody which recognizes DR determinants. Only 35% of the cells expressed single, focal accumulations of alpha-naphthyl-acid esterase activity, which is a characteristic of T.M cells, but 85% of them showed this focal staining pattern with acid phosphatase or beta-glucuronidase. Mononuclear cells from the SS patient showed poor or no proliferative response to phytohemagglutinin, pokeweed mitogen, concanavalin A, purified protein derivative, Candida, and allogeneic cells and lacked both helper and suppressor activity for pokeweed mitogen driven production of IgM and IgG immunoglobulins by normal B cells, but they were able to stimulate a marked proliferative response in mixed-lymphocyte culture. The defective expression of enz...Continue Reading

References

Dec 1, 1976·The Journal of Clinical Investigation·S BroderT A Waldmann
Aug 16, 1973·The New England Journal of Medicine·J C BrouetM Seligmann
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D Zucker-FranklinF Quagliata
Feb 1, 1981·European Journal of Immunology·G CorteA Bargellesi
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G CorteA Bargellesi
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Oct 1, 1980·Journal of Cutaneous Pathology·B CutlerH I Katz

❮ Previous
Next ❯

Citations

Sep 1, 1992·The Journal of Clinical Investigation·A DalloulC Schmitt
Jan 1, 1986·Histopathology·P RomagnoliB Giannotti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.