Abstract
NKT cells are considered unconventional T cells. First, they are restricted by a nonclassical MHC class I molecule, CD1d, which presents glycolipids; second, their TCR repertoire is very limited. After stimulation by their TCR, NKT cells rapidly release large amounts of cytokines, such as IL-4 and IFN-gamma. Little is known about NKT cells present in lymph nodes. In the present report we show that NKT cells are differently distributed in various lymph nodes and are, for instance, abundant in pancreatic and mesenteric lymph nodes of C57BL/6 mice and nonobese diabetic mice. The high frequency of NKT cells in splanchnic lymph nodes is not simply a consequence of inflammatory signals, as draining lymph nodes still contain low frequencies of NKT cells after IFA or CFA injections. NKT cells from splanchnic lymph nodes harbor a Vbeta repertoire similar to that of splenic and liver NKT cells, in contrast to peripheral NKT cells that are not biased toward Vbeta8 segments. Analysis of cytokine production by NKT cells from splanchnic lymph nodes reveals that they produce at least as much IL-4 as IFN-gamma, in contrast to NKT cells from other organs (spleen, liver, and peripheral lymph nodes), which produce much more IFN-gamma than IL-4. T...Continue Reading
References
Sep 1, 1994·The Journal of Experimental Medicine·O Lantz, A Bendelac
May 12, 1995·Science·A BendelacR R Brutkiewicz
Jul 1, 1996·The Journal of Experimental Medicine·E Y DenkersA Sher
Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
Dec 31, 1997·Science·J CuiM Taniguchi
Dec 31, 1997·Science·T KawanoM Taniguchi
Jan 15, 1998·Nature·S B WilsonD A Hafler
Oct 13, 1998·Immunity·G Eberl, H R MacDonald
Nov 17, 1998·The Journal of Experimental Medicine·A LehuenR C Monteiro
Jan 20, 1999·The Journal of Experimental Medicine·P HöglundD Mathis
Apr 6, 1999·The Journal of Experimental Medicine·H KitamuraT Nishimura
Nov 11, 1999·European Journal of Immunology·K J HammondD I Godfrey
Jan 6, 2000·The Journal of Experimental Medicine·Y KanekoM Taniguchi
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S PiedP A Cazenave
Feb 24, 2000·The Journal of Experimental Medicine·M J SmythD I Godfrey
Mar 14, 2000·Immunity·J E GumperzS M Behar
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I ApostolouP Kourilsky
Sep 7, 2000·The Journal of Experimental Medicine·J L MatsudaM Kronenberg
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M C Leite-de-MoraesM Dy
Nov 30, 2000·Immunology Today·D I GodfreyA G Baxter
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E PálT Yamamura
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C RonetG Gachelin
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C CarnaudA Herbelin
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V LalouxA Lehuen
May 23, 2001·The Journal of Experimental Medicine·N KadowakiY J Liu
Jun 30, 2001·International Immunology·L D PoultonA G Baxter
Sep 5, 2001·Nature Medicine·S HongL Van Kaer
Sep 5, 2001·Nature Medicine·S SharifA Herbelin
Citations
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jan NovakAgnès Lehuen
Apr 6, 2012·PLoS Pathogens·Chi-Ling FuMichael H Hsieh
Jul 31, 2013·Diabetes·Liana GhazarianAgnès Lehuen
Jan 7, 2015·Clinical and Experimental Immunology·D Petrovic-DjergovicS Partida-Sánchez
Mar 14, 2008·Clinical Science·Lucy FaircloughJonathan R Lamb
Jan 18, 2006·Clinical and Experimental Immunology·S L Cardell
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Guang ChenDavid V Serreze
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jan NovakAgnès Lehuen
Sep 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jakob Ørskov SørensenCarl-Henrik Brogren
Jun 16, 2015·Frontiers in Immunology·Drew Slauenwhite, Brent Johnston
Jul 6, 2018·Frontiers in Immunology·S Harsha Krovi, Laurent Gapin
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naoto MatsukiSebastian Joyce
Jun 24, 2008·Journal of Immunotoxicology·Tomer Adar, Yaron Ilan
Dec 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bo PeiMitchell Kronenberg
Jul 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean-Marc DoisneKamel Benlagha
Sep 6, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria L AllendeRichard L Proia
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christoph H TrippPatrizia Stoitzner
Dec 23, 2010·Immunotherapy·Luc Van KaerLan Wu
Dec 31, 2004·Immunological Investigations·Novica M MilićevićJürgen Westermann
Oct 16, 2002·Infection and Immunity·Alissa ChackerianSamuel M Behar
Jun 24, 2008·Journal of Immunotoxicology·François D DufourAlan G Baxter
Jul 25, 2012·Clinical and Experimental Medicine·Jan Novak, Lucie Novakova
Nov 30, 2019·Clinical Reviews in Allergy & Immunology·Chao HuangZhigang Tian
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brent JohnstonEugene C Butcher
Apr 25, 2007·International Reviews of Immunology·Jan NovakAgnès Lehuen
Nov 27, 2008·The Journal of Clinical Investigation·Carmela De SantoVincenzo Cerundolo
Mar 17, 2010·Nature Immunology·Patricia BarralFacundo D Batista
Dec 29, 2020·Clinical Microbiology Reviews·Nicolás M S GálvezAlexis M Kalergis