Phenotypic and functional differences between NKT cells colonizing splanchnic and peripheral lymph nodes

The Journal of Immunology : Official Journal of the American Association of Immunologists
V LalouxAgnès Lehuen

Abstract

NKT cells are considered unconventional T cells. First, they are restricted by a nonclassical MHC class I molecule, CD1d, which presents glycolipids; second, their TCR repertoire is very limited. After stimulation by their TCR, NKT cells rapidly release large amounts of cytokines, such as IL-4 and IFN-gamma. Little is known about NKT cells present in lymph nodes. In the present report we show that NKT cells are differently distributed in various lymph nodes and are, for instance, abundant in pancreatic and mesenteric lymph nodes of C57BL/6 mice and nonobese diabetic mice. The high frequency of NKT cells in splanchnic lymph nodes is not simply a consequence of inflammatory signals, as draining lymph nodes still contain low frequencies of NKT cells after IFA or CFA injections. NKT cells from splanchnic lymph nodes harbor a Vbeta repertoire similar to that of splenic and liver NKT cells, in contrast to peripheral NKT cells that are not biased toward Vbeta8 segments. Analysis of cytokine production by NKT cells from splanchnic lymph nodes reveals that they produce at least as much IL-4 as IFN-gamma, in contrast to NKT cells from other organs (spleen, liver, and peripheral lymph nodes), which produce much more IFN-gamma than IL-4. T...Continue Reading

References

May 12, 1995·Science·A BendelacR R Brutkiewicz
Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
Nov 11, 1999·European Journal of Immunology·K J HammondD I Godfrey
Feb 24, 2000·The Journal of Experimental Medicine·M J SmythD I Godfrey
Mar 14, 2000·Immunity·J E GumperzS M Behar
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I ApostolouP Kourilsky
Sep 7, 2000·The Journal of Experimental Medicine·J L MatsudaM Kronenberg
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M C Leite-de-MoraesM Dy
Nov 30, 2000·Immunology Today·D I GodfreyA G Baxter
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E PálT Yamamura
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C RonetG Gachelin
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C CarnaudA Herbelin
Jun 30, 2001·International Immunology·L D PoultonA G Baxter

❮ Previous
Next ❯

Citations

Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jan NovakAgnès Lehuen
Apr 6, 2012·PLoS Pathogens·Chi-Ling FuMichael H Hsieh
Jan 7, 2015·Clinical and Experimental Immunology·D Petrovic-DjergovicS Partida-Sánchez
Mar 14, 2008·Clinical Science·Lucy FaircloughJonathan R Lamb
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Guang ChenDavid V Serreze
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jan NovakAgnès Lehuen
Sep 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jakob Ørskov SørensenCarl-Henrik Brogren
Jun 16, 2015·Frontiers in Immunology·Drew Slauenwhite, Brent Johnston
Jul 6, 2018·Frontiers in Immunology·S Harsha Krovi, Laurent Gapin
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naoto MatsukiSebastian Joyce
Jun 24, 2008·Journal of Immunotoxicology·Tomer Adar, Yaron Ilan
Dec 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bo PeiMitchell Kronenberg
Jul 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean-Marc DoisneKamel Benlagha
Sep 6, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria L AllendeRichard L Proia
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christoph H TrippPatrizia Stoitzner
Oct 16, 2002·Infection and Immunity·Alissa ChackerianSamuel M Behar
Jun 24, 2008·Journal of Immunotoxicology·François D DufourAlan G Baxter
Jul 25, 2012·Clinical and Experimental Medicine·Jan Novak, Lucie Novakova
Nov 30, 2019·Clinical Reviews in Allergy & Immunology·Chao HuangZhigang Tian
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brent JohnstonEugene C Butcher
Apr 25, 2007·International Reviews of Immunology·Jan NovakAgnès Lehuen
Dec 29, 2020·Clinical Microbiology Reviews·Nicolás M S GálvezAlexis M Kalergis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

The International Journal of Biochemistry & Cell Biology
Jason C MercerAvery August
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology
Sachiko Miyake
The Journal of Immunology : Official Journal of the American Association of Immunologists
G EberlH R MacDonald
The Journal of Immunology : Official Journal of the American Association of Immunologists
Sally C KentDavid A Hafler
© 2022 Meta ULC. All rights reserved