Phenotypic and functional profile of Th17 and Treg cells in allergic fungal sinusitis

International Immunopharmacology
Gargi RaiSajad Ahmad Dar

Abstract

Interleukin-17 producing T helper (Th17) and regulatory T cells (Treg) cells have been identified to play a critical role in atopic inflammation. However, conflicting reports on the role of Th17/Treg cells in allergic fungal rhinosinusitis (AFRS) patients of different ethnicities has mystified its pathogenesis. To better understand the pathophysiological mechanisms involved in AFRS, we conducted a prospective, analytical, case-control study involving 40 confirmed immunocompetent AFRS patients and 20 healthy controls. The distribution of Th17 and Treg cells in PBMC, intracellular mRNA expression of retinoid orphan nuclear receptor (RORγt) in Th17 and forkhead transcription factor (FoxP3) in Treg cells, and serum cytokine levels were investigated. Aspergillus flavus was identified from majority (85%) of patient tissue biopsies. Total serum IgE level along with cytokines IL-17, IL-21, IL-1β and TGF-β were comparatively elevated in AFRS. Nevertheless, IL-2 and IL-10 were reduced. Higher percentages of CD3+CD4+ T cells in AFRS with increased expression of CD161 and/or IL-23R markers were observed. Though, lower percentages of CD4+CD25+ Treg cells with elevated expression of GITR were patent. Transcription factor RORγt mRNA was upreg...Continue Reading

Citations

Mar 21, 2019·International Forum of Allergy & Rhinology·Neil N PatelNoam A Cohen
Dec 31, 2019·Case Reports in Otolaryngology·Yuma MatsumotoKoichiro Saito
Jan 18, 2019·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Qingbin LiuWei Wang
Mar 5, 2019·Laryngoscope Investigative Otolaryngology·Sonya MarcusSarah K Wise
Jul 2, 2019·Molecular Medicine Reports·Lanfei ZhouYisen Shao
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Related Papers

Clinical and Experimental Dermatology
D A Bassiouny, O Shaker
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Yuejun LiuHaiyan Liu
© 2022 Meta ULC. All rights reserved