Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells

Mediators of Inflammation
Gap Ryol Lee

Abstract

Regulatory T (Treg) cells maintain immune homeostasis by suppressing excessive immune responses. Treg cells induce tolerance against self- and foreign antigens, thus preventing autoimmunity, allergy, graft rejection, and fetus rejection during pregnancy. However, Treg cells also infiltrate into tumors and inhibit antitumor immune responses, thus inhibiting anticancer therapy. Depleting whole Treg cell populations in the body to enhance anticancer treatments will produce deleterious autoimmune diseases. Therefore, understanding the precise nature of tumor-infiltrating Treg cells is essential for effectively targeting Treg cells in tumors. This review summarizes recent results relating to Treg cells in the tumor microenvironment, with particular emphasis on their accumulation, phenotypic, and functional properties, and targeting to enhance the efficacy of anticancer treatment.

References

Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Dec 2, 2004·Nature Reviews. Immunology·Dmitry Gabrilovich
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ajay V MakerSteven A Rosenberg
Nov 26, 2005·The Journal of Clinical Investigation·Jens DannullJohannes Vieweg
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cécile BadoualEric Tartour
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca FallarinoPaolo Puccetti
Jan 27, 2007·Blood·Karin FischerMarina Kreutz
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gang Zhou, Hyam I Levitsky
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Deirdre O'MahonyJohn E Janik
Mar 26, 2008·The Journal of Experimental Medicine·Silvia PiconeseMario P Colombo
Jun 21, 2008·Nature Reviews. Immunology·Dario A A VignaliCreg J Workman
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul SalamaBarry Iacopetta
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcus C B TanDavid C Linehan
Mar 13, 2009·Nature Reviews. Cancer·Johanna A Joyce, Jeffrey W Pollard
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christy RalphFiona C Thistlethwaite
Mar 2, 2010·Biochimica Et Biophysica Acta·S NizarA Dalgleish
May 13, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun MitsuiHiroshi Shiku
Aug 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua D MezrichChristopher A Bradfield
Aug 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joannes F M JacobsGosse J Adema
Nov 19, 2010·Critical Reviews in Immunology·Adam W Mailloux, M Rita I Young
Feb 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan D MichalekJeffrey C Rathmell
Jun 7, 2011·Cancer Immunology, Immunotherapy : CII·Sylvain LadoireFrançois Ghiringhelli
Jul 2, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiroyuki TaoHiroshi Ueoka
Jul 15, 2011·Nature·Andrea FacciabeneGeorge Coukos
Jan 10, 2012·Annual Review of Immunology·Giorgio Trinchieri
Feb 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takashi IshidaRyuzo Ueda
Mar 16, 2012·International Journal of Cancer. Journal International Du Cancer·Naruyasu KakitaNorio Hayashi
Mar 24, 2012·Cancer Cell·Douglas Hanahan, Lisa M Coussens
Apr 19, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ronald J deLeeuwBrad H Nelson

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Citations

Jan 27, 2019·Expert Review of Anticancer Therapy·Costanza CaninoCamillo Porta
Nov 11, 2020·Biological Chemistry·Moein DehbashiWilliam C Cho
Jun 13, 2019·Cancer Immunology Research·Raghu P KataruBabak J Mehrara
Dec 17, 2019·International Immunopharmacology·Vida HashemiFarhad Jadidi-Niaragh
Feb 6, 2021·Biological Chemistry·Moein DehbashiWilliam C Cho
Jun 1, 2021·Frontiers in Oncology·Moein DehbashiMazdak Ganjalikhani-Hakemi
Jun 29, 2021·Frontiers in Immunology·Ellen N ScottDario A A Vignali
Jul 22, 2021·Pigment Cell & Melanoma Research·Juliano T FreitasLidia Kos

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