Phenotypic and genotypic variation of feline calicivirus during persistent infection of cats

Veterinary Microbiology
L C KreutzB S Seal

Abstract

Amino acid sequence of the capsid protein hypervariable region of nine feline calicivirus (FCV) isolates recovered from cats persistently infected after inoculation with the FCV strain 255 parent virus is reported. Capsid proteins from all the isolates were highly cross reactive by Western blot analysis using polyclonal antisera to FCV. Reverse-transcription PCR was used to obtain sequence information of the FCV capsid protein highly variable E region. Amino acid substitutions occurred between residues 426 and 458 of the FCV capsid protein E region. The sequence data and phylogenetic reconstructions based on the sequence information correlated well with antigenic differences among isolates determined by two-way cross neutralization. These results agree with previous reports using divergent isolates of FCV that correlated amino acid differences with serology. This further supports the hypothesis that the FCV capsid protein E region from residues 426 to 458 contains the serotypic determinants of FCV important to antigenic variation.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Sep 1, 1992·The Journal of General Virology·I D MiltonM J Carter
Sep 1, 1992·Virology·M J CarterP C Turner
Jan 1, 1991·Archives of Virology·Y TohyaT Mikami
Aug 1, 1989·The Journal of General Virology·M J CarterG L Toms
Jun 12, 1986·Nature·L M SmithL E Hood
Mar 3, 1973·The Veterinary Record·R C PoveyH Jessen
Jun 4, 1974·Biochemistry·V GlisinC Byus
Jan 1, 1974·Archiv für die gesamte Virusforschung·D N Love, R F Jones
Oct 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·R A Crandell
May 1, 1983·Analytical Biochemistry·J M Gershoni, G E Palade
Jun 1, 1994·Veterinary Microbiology·Y KawaguchiT Mikami

❮ Previous
Next ❯

Citations

Jan 17, 2007·Veterinary Research Communications·K OheA Taneno
Sep 28, 2007·Veterinary Research Communications·Kyoko OheMotonobu Hara
Sep 29, 1999·Veterinary Microbiology·C Baulch-BrownJ Meanger
Aug 3, 2012·Journal of Virology·Karen P CoyneAlan D Radford
Nov 26, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·James F X WellehanHendrik H Nollens
Sep 23, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kim M PepinRobert McKenna
May 27, 2008·The Veterinary Clinics of North America. Small Animal Practice·Patricia A PesaventoJohn S L Parker
May 27, 2008·The Veterinary Clinics of North America. Small Animal Practice·David Scott McVey, Melissa Kennedy
May 16, 2006·Veterinary Microbiology·Alan D RadfordRosalind M Gaskell
Mar 26, 2003·Oral Microbiology and Immunology·M J Lommer, F J M Verstraete
Jul 29, 1999·The Journal of Veterinary Medical Science·M HashimotoM Mochizuki
Sep 9, 2004·Current Opinion in Infectious Diseases·Alan D RadfordC Anthony Hart
Feb 14, 2007·Veterinary Research·Alan D RadfordRosalind M Gaskell
Mar 11, 2006·The Journal of General Virology·K P CoyneA D Radford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.