Phenotypic changes in the chemistry of Aspergillus nidulans: influence of culture conditions on mycelial composition

Archives of Microbiology
A M McGetrick, A T Bull


A quantitative study was made of macromolecular (nucleic acids, protein), carbohydrate and mineral (magnesium, potassium and phosphorus) components of Aspergillus nidulans in glucose limited chemostat cultures, under varying conditions of dilution rate, temperature, pH and NaCl concentration. The overall mineral content showed greatest variation in response to changes in culture salinity, which also affected the mycelial carbohydrate content. Concomitant and opposite changes in the content of cations and carbohydrates under conditions of increasing salinity may be interpreted in terms of mycelial osmoregulation. Slight variations in DNA content but gross fluctuations in the level of RNA were noted under the different cultural conditions examined. Co-ordinate changes in RNA and Mg2+ contents were evident only under certain conditions: dilution rate from 0.05--0.07 h-1 or temperature from 22--30 degrees C. The constant molar stoichiometry between RNA and Mg2+ characteristic of unicellular microorganisms was not a feature of fungal growth. The protein content was most affected by shifts of temperature and reached minimal values at 25 and 50 degrees C. The growth environment had a marked influence on the protein synthesising activi...Continue Reading


Jan 1, 1977·Advances in Microbial Physiology·A T Bull, A P Trinci
Jan 1, 1979·The International Journal of Biochemistry·A SkładanowskiM Zydowo
May 3, 1976·Archives of Microbiology·H Aiking, D W Tempest
Mar 1, 1973·Biotechnology and Bioengineering·Y Alroy, S R Tannenbaum
Jan 1, 1967·Archiv für Mikrobiologie·W Harder, H Veldkamp
Jan 1, 1969·Journal of Bacteriology·C M Brown, A H Rose
Jun 1, 1965·Journal of General Microbiology·D W TempestJ Sykes

Related Concepts

Carbohydrate nutrients
Magnesium Measurement
RNA, Fungal
Phosphate Measurement
Red Phosphorus
Protein Biosynthesis

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