Phenotypic characterisation of respecified visual cortex subsequent to prenatal enucleation in the monkey: development of acetylcholinesterase and cytochrome oxidase patterns

The Journal of Comparative Neurology
C DehayH Kennedy

Abstract

Prenatal bilateral enucleation induces cortex, which normally would have become striate cortex, to follow a default developmental pathway and to take on the cytoarchitectonic appearance of extrastriate cortex (default extrastriate cortex, Dehay et al. [1996] J. Comp. Neurol. 367:70-89). We have investigated if this manipulation influences the cortical expression of acetylcholinesterase (AChE) and cytochrome oxidase (CO). Early enucleation (before embryonic day 81; E81) had only minor effects on the distribution of AChE and CO in the striate cortex. In animals that underwent operation, the striate cortex CO blobs were significantly more closely spaced on the operculum compared with the calcarine. After early enucleation, there was a periodic distribution of CO dense patches in default extrastriate cortex. These CO patches had a center-to-center spacing that was considerably smaller than that of CO stripes in normal area V2, but was somewhat larger than that of the CO blobs in striate cortex. Although the CO stripes characteristic of normal area V2 could not be detected, there were some high-frequency CO patches, similar to those found in default extrastriate cortex. Early enucleation caused a failure to form the transient AChE b...Continue Reading

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Citations

Oct 10, 2008·Cerebral Cortex·Sarah J Karlen, Leah Krubitzer
May 22, 2007·Nature Reviews. Neuroscience·Colette Dehay, Henry Kennedy
Sep 20, 2017·Cerebral Cortex·Isabel ReilloVíctor Borrell
Jul 6, 2018·Annual Review of Vision Science·Ione Fine, Ji-Min Park
Sep 27, 2019·Neuron·Cathryn R CadwellTomasz J Nowakowski
Sep 18, 2002·Brain Research. Developmental Brain Research·Marcy A KingsburyBarbara L Finlay

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