Phenotypic Characteristics in GBA-Associated Parkinson's Disease: A Study in a Greek Population

Journal of Parkinson's Disease
Athina SimitsiLeonidas Stefanis

Abstract

We compared phenotypic characteristics in 35 Greek patients with Parkinson's disease (PD), carriers of GBA1 mutations (GBA-PD), with 35 Genetically Unidentified PD patients (GU-PD). We found a previously reported higher prevalence of cognitive impairment and a little appreciated more frequent bilateral onset of the disease in GBA-PD vs GU-PD. As far as the exposure to environmental factors, linked to PD, is concerned, our study hints to the possibility that pesticide exposure may be more common in GBA-PD patients, and possibly act synergistically with the mutation carrier status to trigger the disease.

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Citations

Feb 27, 2020·Journal of Clinical Medicine·Silvia PaciottiTommaso Beccari
Dec 5, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Stylianos RavanidisEpaminondas Doxakis
Oct 11, 2020·Brain Sciences·Efthalia AngelopoulouChristina Piperi
Feb 21, 2021·Molecular Neurobiology·Efthalia AngelopoulouChristina Piperi

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