PMID: 8954173Jan 1, 1996Paper

Phenotypic characteristics of Epstein-Barr-virus-associated gastric carcinomas

Journal of Cancer Research and Clinical Oncology
S MoritaniT Hattori

Abstract

We identified Epstein-Barr-virus(EBV)-associated gastric carcinomas by in situ hybridization that targets EBV-encoded small RNA, and investigated their phenotypic characteristics by mucin histochemistry. Out of 132 gastric carcinomas, 15 were EBV-positive, and they were exclusively located at the proximal part of the stomach; 8 were early and 7 were advanced carninomas. Out of the 15 EBV-positive carcinomas, 10 were so-called gastric carcinoma with lymphoid stroma (GCLS); 4 of the other 5 tumours were moderately differentiated adenocarcinoma (tub 2) showing a "lace pattern". This pattern was also seen in the intramucosal parts of 6 (3 early and 3 advanced) GCLS. As for the mucin phenotype of the cancer cells, the gastric type was predominant in the EBV-positive tumours, while the EBV-negative tumours, even with the lace pattern or GCLS, showed phenotypes other than the gastric type (intestinal or mixture of intestinal and gastric). It was inferred that EBV-positive gastric carcinomas show tub 2 with the lace pattern and gastric phenotype in earlier stages, and become GCLS during the tumour progression, but the gastric phenotype tends to remain throughout the history.

References

Apr 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T Katsuyama, S S Spicer
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Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·R RoubinP Burtin
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Mar 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S S SPICER

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Citations

Apr 2, 2009·Journal of Gastroenterology and Hepatology·Ju-Han LeeYoung-Sik Kim
Apr 9, 2016·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jong-Myon Bae, Eun Hee Kim
Nov 24, 2004·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Vuka KatićDragoljub Popović
May 23, 2015·Medicine·Xin-Zu ChenHermann Brenner

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