Phenotypic Characteristics of PD-1 and CTLA-4 Expression in Symptomatic Acute Hepatitis A

Gut and Liver
Hyosun ChoChang Don Lee

Abstract

The immunoregulatory molecules programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are associated with the dysfunction of antiviral effector T-cells, which leads to T-cell exhaustion and persistent viral infection in patients with chronic hepatitis C and chronic hepatitis B. Little is known about the role of PD-1 and CTLA-4 in patients with symptomatic acute hepatitis A (AHA). Peripheral blood mononuclear cells were isolated from seven patients with AHA and from six patients with nonviral acute toxic hepatitis (ATH) during the symptomatic and convalescent phases of the respective diseases; five healthy subjects acted as controls. The expression of PD-1 and CTLA-4 on T-cells was measured by flow cytometry. PD-1 and CTLA-4 expression during the symptomatic phase was significantly higher in the T-cells of AHA patients than in those of ATH patients or healthy controls (PD-1 18.3% vs 3.7% vs 1.6%, respectively, p<0.05; CTLA-4 23.5% vs 6.1% vs 5.9%, respectively, p<0.05). The levels of both molecules decreased dramatically during the convalescent phase of AHA, whereas a similar pattern was not seen in ATH. Our findings are consistent with a viral-protective effect of PD-1 and CTLA-4 as inhibitory molecu...Continue Reading

References

Jun 1, 1987·European Journal of Epidemiology·P De FilippisA Panà
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May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed ElrefaeiHuyen Cao
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Apr 7, 2010·The Korean Journal of Hepatology·So Young Kwon

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Citations

Jul 14, 2017·International Journal of Molecular Sciences·Hyosun ChoChang Wook Kim
May 23, 2018·International Journal of Molecular Medicine·Hui CaoWei Zhang
Apr 9, 2020·Frontiers in Immunology·Jil M JubelFrank A Schildberg

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Methods Mentioned

BETA
flow cytometry

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