Phenotypic characterization of enzymatic activity of clinical dermatophyte isolates from animals with and without skin lesions and humans

Journal of Applied Microbiology
Sebastian GnatPrzemyslaw Zieba

Abstract

The pathogenesis of dermatophytoses is associated with the secretion of enzymes degrading the infected tissue components. Although many studies on enzymatic activity of dermatophytes have been conducted over the years, there have been no concrete proposals on the construction of the profile of enzymes characteristic of individual species, genus or ecological types of dermatophytes. The aim of this study was to assess the capability of clinical dermatophyte isolates from both symptomatic and asymptomatic animals and humans to produce different enzymes. Clinical isolates of 234 dermatophyte strains collected during routine examination of animal health were used in this study. The enzymatic production of keratinase, elastase, phospholipase, lipase, protease, DNase and gelatinase as well as the haemolytic activity were evaluated using specific test media. The overall degree of enzymatic activity of the analysed clinical isolates of the dermatophytes was 67%. All tested clinical isolates of different species of dermatophytes showed keratinase activity and 96% additionally exhibited phospholipase activity. The weakest activity among the tested enzymes was demonstrated for elastase and gelatinase. 83% of the isolates of the dermatophy...Continue Reading

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Citations

Feb 6, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·J Hesse-MacabataC Wiegand
May 6, 2019·Journal of Medical Microbiology·Sebastian GnatPrzemysław Zięba
Feb 13, 2020·Journal of Applied Microbiology·S GnatA Nowakiewicz
May 15, 2020·Transboundary and Emerging Diseases·Sebastian GnatMariusz Dyląg
Jul 2, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Sebastian GnatŁukasz Kopiński
Aug 28, 2020·Biofouling·Débora de Souza Collares Maia Castelo-BrancoMarcos Fábio Gadelha Rocha
Jan 23, 2021·Mycoses·Giovanna Azevedo CelestrinoMaria Glória Teixeira Sousa
Apr 4, 2021·Antibiotics·Chioma Inyang AnekeClaudia Cafarchia
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Dominik ŁagowskiAleksandra Trościańczyk

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