Phenotypic Characterization of Juvenile Idiopathic Arthritis in African American Children

The Journal of Rheumatology
Lauren FitzpatrickCARRA Registry Investigators

Abstract

Juvenile idiopathic arthritis (JIA) affects children of all races. Prior studies suggest that phenotypic features of JIA in African American (AA) children differ from those of non-Hispanic white (NHW) children. We evaluated the phenotypic differences at presentation between AA and NHW children enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, and replicated the findings in a JIA cohort from a large center in the southeastern United States. Children with JIA enrolled in the multicenter CARRA Registry and from Emory University formed the study and replication cohorts. Phenotypic data on non-Hispanic AA children were compared with NHW children with JIA using the chi-square test, Fisher's exact test, and the Wilcoxon signed-rank test. In all, 4177 NHW and 292 AA JIA cases from the CARRA Registry and 212 NHW and 71 AA cases from Emory were analyzed. AA subjects more often had rheumatoid factor (RF)-positive polyarthritis in both the CARRA (13.4% vs 4.7%, p = 5.3 × 10(-7)) and the Emory (26.8% vs 6.1%, p = 1.1 × 10(-5)) cohorts. AA children had positive tests for RF and cyclic citrullinated peptide antibodies (CCP) more frequently, but oligoarticular or early onset antinuclear antibody (ANA)-pos...Continue Reading

References

Aug 1, 2006·Rheumatology·R Gutiérrez-SuárezUNKNOWN Pediatric Rheumatology International Trials Organisation (PRINTO)
Mar 6, 2007·Lancet·Angelo Ravelli, Alberto Martini
May 29, 2007·Arthritis and Rheumatism·R K SaurenmannE D Silverman
Mar 21, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Mustafa YilmazMehmet Kilic
Jul 23, 2008·Pediatric Rheumatology Online Journal·Sampath Prahalad, David N Glass
Oct 14, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jolanda M WhiteBenjamin D Gold
Oct 12, 2012·Pediatric Rheumatology Online Journal·Kate WeakleyChristiaan Scott
Nov 5, 2013·The Journal of Rheumatology·Sheila T Angeles-HanUNKNOWN CARRA Registry Investigators

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Citations

Sep 22, 2018·Clinical Rheumatology·Hatice Ezgi BarisFatma Dedeoglu
Jun 1, 2019·Arthritis Care & Research·Beverly KhodraElizabeth D Ferucci
Feb 18, 2021·Pediatric Rheumatology Online Journal·Iris ReyhanAndreas Reiff

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