Phenotypic characterization of nanshi oral liquid alters metabolic signatures during disease prevention

Scientific Reports
Aihua ZhangXijun Wang

Abstract

This paper was designed to investigate the phenotypic characterization of Nanshi Oral Liquid (NOL) alters metabolic signatures of the 'Kidney Yang Deficiency syndrome' (KYDS). Urine metabolites were profiled by UPLC-ESI-Q-TOF-HDMS. The significantly changed metabolites such as xanthurenic acid, 4,8-dihydroxyquinoline, 3-methyldioxyindole, 4,6-dihydroxyquinoline, kynurenic acid, hippuric acid, taurine, tyramine, and 3-metanephrine, had been identified, and were related to the disturbance in tyrosine metabolism, steroid hormone biosynthesis, taurine and hypotaurine metabolism, tryptophan metabolism, phenylalanine metabolism and lysine degradation, which were helpful to further understanding the KYDS and intervention mechanism of NOL. The biochemical result showed that NOL can alleviate the kidney impairment induced by KYDS. Metabolomics results indicated the significantly changed metabolites were found to be reasonable in explaining the action mechanism of NOL. Interestingly, the effectiveness of NOL against KYDS was proved using the established metabolomics method and regulated the biomarkers as well as adjusted the metabolic disorder pathways. NOL had potentially pharmacological effect through regulating multiple perturbed path...Continue Reading

References

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Citations

Dec 24, 2016·Mass Spectrometry Reviews·Aihua ZhangXijun Wang
Jun 27, 2018·Pharmacological Reviews·Raul R GainetdinovMark D Berry
May 23, 2020·Critical Reviews in Food Science and Nutrition·Shubo LiHongshun Yang
Dec 1, 2019·International Journal of Molecular Sciences·Dmitry L MaslovPetr G Lokhov
Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yumei WangJicheng Liu
Nov 13, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jimei XiaoZhengao Sun
Nov 2, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Muhammad RamzanSyed Ghulam Musharraf
Aug 27, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shao-Bo LiuXi-Jun Wang

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Methods Mentioned

BETA
NMR
PCA
light microscopy

Software Mentioned

DA
MetaboAnalyst
OPLS
EZinfo
Progenesis QI
SPSS
Motic Medical

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