Mar 29, 2020

Brain structures associated with reading and their abnormalities in dyslexia: a wholebrainanalysis

BioRxiv : the Preprint Server for Biology
Takaaki HorinouchiChikara Furusawa


Developmental dyslexia (DD) is a highly prevalent neurodevelopmental disorder, which is devastating for individuals in modern societies in which fluent reading skill is mandatory for leading a normal life. Research on the neural origins of DD has continued for half a century, yielding, however, inconsistent results. It has also lacked a thorough characterization of the association between abnormal neuroanatomy and skills vital for reading. The current study was set out to determine abnormalities of grey and white matter volumes in adults with DD and associations between brain structures and reading and related skills. To this end, we conducted a whole-brain voxel based morphometry following current guidelines on state-of-the-art analysis approaches and rigorous neuropsychological testing. We found decreased volumes of grey matter in DD, comprising a left-hemispheric network including superior temporal and inferior frontal gyri, insula, the limbic system, and basal ganglia, and white matter, including the right middle temporal gyrus and hippocampus. These results are both consistent with the most robust previous findings on structural abnormalities in the left frontotemporal network in DD and yield novel insight to the role of s...Continue Reading

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