Phenotypic definition of effector and memory T-lymphocyte subsets in mice chronically infected with Mycobacterium tuberculosis.

Clinical and Vaccine Immunology : CVI
Marcela Henao-TamayoIan M Orme

Abstract

The bacterium Mycobacterium tuberculosis remains one of the world's most successful pathogens, a situation that is aggravated by the fact that the existing vaccine, Mycobacterium bovis BCG, is not effective in adults. As with any vaccine, the purpose of giving BCG vaccination is to establish a long-lived state of memory immunity, but whether this is successfully completely established is still unclear. It is generally accepted that memory T cells can be divided into central and effector memory populations by function and by phenotype; however, the majority of data supporting this division have been generated using transgenic mouse models or mice that have recovered from acute viral infections. Tuberculosis, on the other hand, represents a persistent, chronic state of immunity in which the presence of memory T cells is far less well defined. We show here that mice vaccinated with BCG or chronically infected with M. tuberculosis establish antigen-specific populations of cells within the lungs that predominantly express a cellular phenotype consistent with their being effector or effector memory cells. In contrast, cells with a central memory phenotype exist in much lower numbers in the lungs but can be found in significantly larg...Continue Reading

References

Jun 1, 1986·Tubercle·I M Orme, F M Collins
Jun 1, 1993·The Journal of Infectious Diseases·I M OrmeW H Boom
Oct 26, 1999·Molecular Medicine Today·I M Orme
Jun 3, 2000·Annual Review of Immunology·F SallustoA Lanzavecchia
Oct 19, 2000·Current Topics in Microbiology and Immunology·F SallustoA Lanzavecchia
Jan 5, 2002·Trends in Microbiology·Pablo J BifaniBarry N Kreiswirth
Dec 20, 2002·Nature·Michael J Bevan
Feb 4, 2003·Nature Immunology·E John WherryRafi Ahmed
Mar 23, 2004·Annual Review of Immunology·Federica SallustoAntonio Lanzavecchia
Nov 6, 2004·Seminars in Immunology·Tania S GourleyRafi Ahmed
May 12, 2005·Current Opinion in Immunology·Antonio Lanzavecchia, Federica Sallusto
Jun 28, 2005·Trends in Immunology·Francesca Di Rosa, Reinhard Pabst
Sep 13, 2005·Nature Immunology·Lois L CavanaghUlrich H von Andrian
Jul 11, 2006·Immunological Reviews·Charles D SurhJonathan Sprent
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arati KamathSamuel M Behar
Feb 16, 2007·The New England Journal of Medicine·Mario C Raviglione, Ian M Smith
Oct 26, 2007·European Journal of Immunology·Anne LetschCarmen Scheibenbogen
Jan 24, 2008·Immunologic Research·K Kai McKinstrySusan L Swain
Jul 17, 2008·Immunologic Research·Timothy W Hand, Susan M Kaech
Mar 3, 2009·Expert Review of Vaccines·Andre TanelRafick-Pierre Sékaly
Mar 20, 2009·Nature Immunology·Leo Lefrançois, David Masopust
Mar 21, 2009·Seminars in Immunology·Stephen P Schoenberger

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Citations

Jan 8, 2013·The Journal of Infectious Diseases·Andreia P SoaresWillem A Hanekom
Aug 24, 2012·Clinical and Vaccine Immunology : CVI·Nancy D MarínLuis F García
Sep 13, 2003·American Journal of Respiratory and Critical Care Medicine·Deborah A LewinsohnDavid M Lewinsohn
Dec 19, 2009·American Journal of Respiratory and Critical Care Medicine·Xinchun ChenBoping Zhou
Jan 5, 2011·PLoS Pathogens·Hannah Priyadarshini GideonRobert John Wilkinson
Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Niels Peter H KnudsenClaus Aagaard
Jul 6, 2014·Tuberculosis·Marcela Henao-TamayoIan M Orme
Nov 28, 2012·Expert Review of Vaccines·Neha Dalmia, Alistair J Ramsay
Feb 13, 2016·EBioMedicine·Karen A O MartinsSina Bavari
Dec 22, 2012·Microbial Pathogenesis·Jonathan M PittAnne O'Garra
Mar 21, 2012·Tuberculosis·Marcela Henao-TamayoIan M Orme
Jul 28, 2010·Tuberculosis·Ian M Orme
Jun 1, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·L C R SilvaG Benard
Feb 13, 2008·Immunity & Ageing : I & a·Lesya M Pinchuk, Nikolay M Filipov
Apr 26, 2011·Vaccine·Andrés Obregón-HenaoFabiana Bigi
Oct 26, 2013·Tuberculosis·Ian M Orme
Apr 30, 2014·Frontiers in Immunology·Adeliane Castro da CostaAna Paula Junqueira-Kipnis
Nov 28, 2014·Microbiology and Molecular Biology Reviews : MMBR·Thomas R HawnSteven G Self
Aug 31, 2016·The Journal of Infectious Diseases·Dhiraj Kumar SinghGobardhan Das
Jun 1, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiu-Zhi WuHuan-Zhong Shi
Oct 20, 2017·Clinical and Vaccine Immunology : CVI·Thomas H KingIan M Orme
Jun 26, 2015·Clinical and Vaccine Immunology : CVI·A D WhiteS A Sharpe
Dec 30, 2014·Clinical and Vaccine Immunology : CVI·Ian M Orme

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