Phenotypic Detection and Antibiogram of β-lactamase-producing Proteus Species in a Tertiary Care Hospital, India

Annals of Medical and Health Sciences Research
N PalR K Maheshwari

Abstract

Proteus species cause a variety of community- and hospital-acquired illnesses. Synthesis of β-lactamases is the predominant mechanism for resistance to β-lactam antibiotics. Among the β-lactamases, extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases are the most common. The objective of this study was to determine the occurrence of ESBL and AmpC β-lactamases in Proteus species among various clinical isolates at a tertiary care hospital, India. This study was done to identify various species of Proteus from clinical samples (n = 3922). Antimicrobial susceptibility was performed by Kirby-Bauer disc diffusion method. ESBL production was detected by modified double-disc synergy test and indirect modified three-dimensional tests and AmpC β-lactamase production by AmpC disc test and modified Hodge test. Proteus species were isolated in 5.4% (101/1876) specimens. Three Proteus species isolated were Proteus mirabilis 62.4% (63/101), Proteus vulgaris 29.7% (30/101), and Proteus penneri 7.9% (8/101). ESBL producers confirmed by both tests were of 88.1% (89/101). Only AmpC β-lactamase was produced by four isolates. Coproduction of ESBL and AmpC β-lactamase was observed in 58.4% (52/89) of isolates. Twelve isolates were non-β-lact...Continue Reading

Citations

Jul 12, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Ming-Feng LinHan-Yueh Kuo
Mar 25, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Elizabeth Maria Bispo BeltrãoAna Catarina de Souza Lopes
May 16, 2021·The Journal of International Medical Research·Ala'a MatalkaKhaled Al Oweidat

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