Phenotypic differences of CD4(+) T cells in response to red blood cell immunization in transfused sickle cell disease patients

European Journal of Immunology
B VingertF Noizat-Pirenne

Abstract

Alloimmunization against red blood cells (RBCs) is the main immunological risk associated with transfusion in patients with sickle cell disease (SCD). However, about 50-70% of SCD patients never get immunized despite frequent transfusion. In murine models, CD4(+) T cells play a key role in RBC alloimmunization. We therefore explored and compared the CD4(+) T-cell phenotypes and functions between a group of SCD patients (n = 11) who never became immunized despite a high transfusion regimen and a group of SCD patients (n = 10) who had become immunized (at least against Kidd antigen b) after a low transfusion regimen. We studied markers of CD4(+) T-cell function, including TLR, that directly control lymphocyte function, and their spontaneous cytokine production. We also tested responders for the cytokine profile in response to Kidd antigen b peptides. Low TLR2/TLR3 expression and, unexpectedly, strong expression of CD40 on CD4(+) T cells were associated with the nonresponder status, whereas spontaneous expression of IL-10 by CD4(+) T cells and weak Tbet expression were associated with the responder status. A Th17 profile was predominant in responders when stimulated by Jb(k) . These findings implicate CD4(+) T cells in alloimmuniz...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·F RoussetJ Banchereau
Sep 12, 1998·Lancet·M AbboudC A Blau
Sep 21, 2002·Science·Christine BourgeoisCorinne Tanchot
Nov 26, 2002·Science·Katsutoshi OzakiWarren J Leonard
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mousa Komai-KomaFoo Y Liew
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew E GelmanLaurence A Turka
Jan 22, 2005·Science·Eun Sook HwangLaurie H Glimcher
Jun 7, 2005·Transfusion·Denis RevironJacques Chiaroni
Jul 15, 2005·Blood·Graham M LordLaurie H Glimcher
Jan 18, 2006·British Journal of Haematology·Jacques ChiaroniDenis Reviron
Mar 6, 2007·The Journal of Allergy and Clinical Immunology·Michio FujiwaraHiroshi Nakajima
May 12, 2007·American Journal of Hematology·Jin YuKarina Yazdanbakhsh
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Federica CapolunghiRita Carsetti
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vicky LampropoulouSimon Fillatreau
Oct 28, 2008·Journal of Autoimmunity·Rocky L BakerKathryn Haskins
Nov 13, 2008·Pediatric Radiology·Rana KhatibSharada A Sarnaik
May 19, 2009·Trends in Immunology·Heike SchmidlinBianca Blom
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas M DurrantDennis W Metzger
Jun 1, 2010·Advances in Immunology·Naoto IshiiKazuo Sugamura
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Meike MitsdoerfferVijay K Kuchroo
Oct 19, 2010·The American Journal of Pathology·Zili ZhangJames T Rosenbaum
Dec 3, 2010·The Journal of Rheumatology·Cécile Toly-NdourRobert Girot
Feb 15, 2011·Annual Review of Immunology·Shane Crotty
Jan 14, 2012·Current Opinion in Immunology·Kenneth J Oestreich, Amy S Weinmann
Mar 7, 2012·Cytokine & Growth Factor Reviews·Bogna J Swiątek
Apr 17, 2012·Cytokine·Akiko ShibuiSusumu Nakae
Oct 30, 2012·Journal of Medical Case Reports·Mouna MaamarMohammed Aouni
Nov 21, 2012·PloS One·Agapitos PatakasPaul Garside
Dec 21, 2012·The Journal of Experimental Medicine·Matthieu PerreauGiuseppe Pantaleo
Jul 28, 2013·Trends in Immunology·Joseph M Reynolds, Chen Dong

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Citations

Sep 12, 2015·American Journal of Hematology·Robert S NickelJeanne E Hendrickson
Oct 29, 2015·Transfusion·Robert Sheppard NickelSean R Stowell
May 31, 2016·American Journal of Hematology·Emmanuel BalandyaJulie Makani
Oct 22, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rahma ElayebBenoît Vingert
Sep 5, 2019·Current Opinion in Hematology·Krystalyn E HudsonRichard O Francis
Oct 18, 2016·Current Opinion in Hematology·Jeanne E HendricksonChristopher A Tormey
Dec 4, 2016·Hematology·Karina Yazdanbakhsh
Jun 7, 2019·British Journal of Haematology·Sanne M MeindertsTimo K van den Berg
Mar 7, 2017·ISBT Science Series·Karina YazdanbakhshChristopher D Hillyer
Oct 11, 2020·Transfusion·Justine CoombsBenoît Vingert
Jan 15, 2021·Blood·France Pirenne
Nov 3, 2020·Mediators of Inflammation·Paula B DaltroVitor Fortuna
Apr 27, 2021·British Journal of Haematology·Marie TamagneBenoît Vingert
Aug 17, 2021·Transfusion Medicine·Phandee WatanaboonyongcharoenPonlapat Rojnuckarin
May 22, 2020·Immunology Letters·Júlia Teixeira Cottas de Azevedo, Kelen Cristina Ribeiro Malmegrim
Aug 27, 2021·Blood·Karina Yazdanbakhsh

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