Phenotypic diversity of the cellular 1,25-dihydroxyvitamin D3-receptor interaction among different genera of New World primates

The Journal of Clinical Endocrinology and Metabolism
J S Adams, M A Gacad


High serum of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] concentrations and target organ resistance to the hormone are characteristic findings in some New World primates (platyrrhines). We examined the abilities of cultural dermal fibroblasts from individual platyrrhines of four different genera, Aotus, Alouatta, Pithecia, and Saguinus, to internalize and respond to 1,25-(OH)2D3 in an attempt to identify possible phenotypic heterogeneity in the 1,25-(OH)2D3-receptor interaction among them. Results were compared to those from two Old World primates (catarrhines), Pan troglodytes and Pongo pygmaeus. Compared to catarrhine cells, cells from Alouatta, Pithecia, and Saguinus demonstrated 1) a 10-fold decrease in [3H] 1,25-(OH)2D3 internalization capacity; 2) a 2- to 5-fold increase in the apparent internalization constant [3H]1,25-(OH)2D3; and 3) a 3- to 15-fold increase in the 1,25-(OH)2D3 concentration required to elicit half-maximal induction of [3H]25-hydroxyvitamin D3-24-hydroxylating activity (ED50; rank order Sanguinus much greater than Pithecia greater than Alouatta). Although the internalization capacity of cells from two different primates in the genus Aotus was 3- to 4-fold lower than that in catarrhine cells, the internaliz...Continue Reading


Dec 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J S AdamsT L Clemens
Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M Lemire, J S Adams
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M A Gacad, J S Adams
Jan 1, 1994·Journal of Medical Primatology·R E WellerH A Ragan
May 1, 1989·The Journal of Clinical Investigation·P F BarnesJ S Adams
Mar 1, 1991·The Journal of Clinical Investigation·M A Gacad, J S Adams
Jan 10, 2003·Journal of Cellular Biochemistry·J S AdamsM A Gacad
Jan 1, 1992·American Journal of Primatology·Mercedes A GacadJohn S Adams
Sep 19, 2017·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Rowena KillickSharon P Redrobe
Nov 12, 2019·Frontiers in Endocrinology·Rene F ChunJohn S Adams
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·John S AdamsJulia Barsony

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