PMID: 2493352Mar 1, 1989Paper

Phenotypic expression of histocompatibility antigens in human primary tumours and metastases

Clinical & Experimental Metastasis
F Ruiz-CabelloC Rivas

Abstract

HLA class I and II expression was studied on 244 (177 primary and 67 metastatic) solid human tumours of different origin. Alkaline immunophosphatase (APAAP) and immunoperoxidase were used on cryostatic sections to stain MHC antigens. Monomorphic MoAbs were used against class I heavy chain, beta 2-microglobulin, DR, DQ and DP molecules. Class I expression was homogeneous on colon, melanoma and epidermoidal primitive tumours. Loss of HLA class I antigens was more frequent on basal cell carcinomas and sarcomas and was related to tumour differentiation on larynx carcinoma. Class I expression was heterogeneous on breast, larynx and stomach primitive neoplasias. Class I negative tumours were more frequent on metastatic than on primitive melanomas. Divergence of class I between primary tumours and autologous metastases was observed on melanomas, larynx and colorectal carcinomas. Class II expression was heterogeneous on all tumours and in a large number of cases was associated with high intensity of leukocytic infiltrate. HLA-DR expression was higher than HLA-DP and HLA-DQ (DR greater than DP greater than DQ) and was related to tumour progression. Four human tumour cell lines were modulated with recombinant interferon-gamma for HLA cla...Continue Reading

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Citations

Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KoretzP Möller
Jul 1, 1990·Clinical & Experimental Metastasis·F EstebanF Garrido
Sep 29, 2011·International Journal of Colorectal Disease·Ming-Chen ZhuFeng Yan
Apr 28, 2000·International Journal of Clinical & Laboratory Research·S PedrinaciF Garrido
Aug 1, 1991·Immunology Letters·F Ruiz-CabelloF Garrido
Aug 1, 1991·Immunobiology·J E FernándezF Garrido
Aug 1, 1991·Scandinavian Journal of Immunology·T CabreraF Garrido
Mar 1, 1993·Annals of the Rheumatic Diseases·M R CohenJ Lundberg
Mar 5, 2003·Annual Review of Immunology·Drew Pardoll
Oct 18, 2002·Expert Review of Anticancer Therapy·Lynn E Spitler
Jan 1, 1991·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·V MattijssenD J Ruiter
Nov 4, 2015·Nature Reviews. Clinical Oncology·Connie Lee BatleviAnas Younes
Oct 10, 2013·International Journal of Cancer. Journal International Du Cancer·Toshiyuki SasakiVadim Jucaud
Aug 1, 1989·Journal of Immunogenetics·A FerronF Garrido
May 30, 2006·Advances in Immunology·Charles G DrakeDrew M Pardoll
Jan 1, 1991·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·F Ruiz-CabelloF Garrido

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