PMID: 4292180Sep 22, 1967Paper

Phenotypic expression of transformation: induction in cell culture by a phorbol ester

Science
A Sivak, B L Van Duuren

Abstract

A biologically potent, tumor-promoting phorbol ester from Croton tiglium L. induces the appearance of transformed clones in a population of contact-inhibited fibroblasts of the mouse cell line 3T3. Mixed populations of cells with 10,000 3T3 cells and 100 virus-transformed cells were exposed to the phorbol ester and, in comparison with untreated cells, showed a marked increase in the numbers of transformed clones that grew. Exposure of 3T3 cultures to the carcinogen 7,12-dimethylbenz(a)anthracene alone or prior to exposure to the phorbol ester did not cause any increase in the number of transformed clones.

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Citations

Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B Djordjevic
Jan 1, 1990·Teratogenesis, Carcinogenesis, and Mutagenesis·D J Fitzgerald, H Yamasaki
Nov 1, 1971·Chemico-biological Interactions·A Sivak, B L Van Duuren
Dec 1, 1995·Mutation Research·H YamasakiV Krutovskikh
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P B FisherH S Ginsberg
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R DulbeccoM Unger
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·N H ColburnG Abruzzo
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Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E G Fey, S Penman
Jun 1, 1991·Environmental Health Perspectives·H Yamasaki
Mar 4, 2014·Advances in Biological Regulation·Gianluca Baldanzi
Jun 1, 1979·Journal of Cellular Physiology·L S Lee, I B Weinstein
Oct 1, 1972·Journal of Cellular Physiology·A Sivak
Feb 4, 1979·Biochimica Et Biophysica Acta·A Sivak
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Nov 1, 1981·Wilhelm Roux's Archives of Developmental Biology·Yoshiki Shiba
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·A Sivak

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