Phenotypic Graphs and Evolution Unfold the Standard Genetic Code as the Optimal

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
Gabriel S Zamudio, Marco V José

Abstract

In this work, we explicitly consider the evolution of the Standard Genetic Code (SGC) by assuming two evolutionary stages, to wit, the primeval RNY code and two intermediate codes in between. We used network theory and graph theory to measure the connectivity of each phenotypic graph. The connectivity values are compared to the values of the codes under different randomization scenarios. An error-correcting optimal code is one in which the algebraic connectivity is minimized. We show that the SGC is optimal in regard to its robustness and error-tolerance when compared to all random codes under different assumptions.

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Citations

May 5, 2018·Transcription·Daewoo PakZachary F Burton
Dec 14, 2018·BMC Evolutionary Biology·Małgorzata WnętrzakPaweł Mackiewicz

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Software Mentioned

SGCrd

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