PMID: 6979245May 1, 1982Paper

Phenotypic heterogeneity of human T-cell malignancies: demonstration by monoclonal antibodies and cytochemical markers

American Journal of Hematology
D M KnowlesL Chess

Abstract

The present study sought to delineate the phenotypic heterogeneity of the human T-cell malignancies. Twenty T-cell neoplasms were investigated for reactivity with the OKT hybridoma monoclonal antibodies and expression of acid alpha-naphthyl acetate esterase (ANAE), beta-glucuronidase (BG), and acid phosphatase (AP) activity. Twelve cases (Mycosis fungoides, Sezary syndrome, cutaneous T-cell lymphoma, chronic lymphocytic leukemia) were OKT3'T4', ie, expressed the phenotype commonly associated with mature T-helper cells. These cases were further divisible into ANAE+BG+ (6 cases), ANAE-BG+ (5 cases), and ANAE-BG- (1 case) phenotypes. In contrast to the 12 OKT3+T4+ cases, the remaining 8 cases showed considerable inter- and intratumor heterogeneity with respect to reactivity with the OKT antibodies. Six of these cases (acute lymphoblastic leukemia, lymphoblastic lymphoma) expressed phenotypes consistent with various intrathymic stages of T-cell differentiation. Five of the latter 6 cases were AP+BG+ANAE-, analogous to the majority of normal cortical thymocytes; an OKT3+T4-T8+T10+ neoplasm was ANAE+, analogous to normal medullary thymocytes. Two cases expressed the previously undescribed OKT3+T4-T8-T10+ phenotype. These studies demo...Continue Reading

References

Dec 1, 1976·The Journal of Clinical Investigation·S BroderT A Waldmann
Jun 1, 1977·British Journal of Haematology·J KulenkampffM F Greaves
Aug 1, 1979·The Journal of Clinical Investigation·E L ReinherzS F Schlossman
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Jul 1, 1976·American Journal of Clinical Pathology·J S Burke, J J Butler
Apr 1, 1980·British Journal of Haematology·G BassoL Zanesco
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman

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Citations

Apr 1, 1983·Journal of Clinical Immunology·I G Barr, B H Toh
Jan 1, 1984·Disease-a-month : DM·J Laurence
Oct 28, 2003·The American Journal of Pathology·Andrew Wallace McGowan MintoAndrew Jackson Rees
May 1, 1983·Scandinavian Journal of Haematology·A Crockard, D Catovsky
Dec 1, 1983·American Journal of Hematology·J P FarcetH Rochant

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