Phenotypic implications of a co-existent haemorrhagic and thrombotic genotype

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Jecko Thachil, Vanessa Martlew

Abstract

Inherited bleeding disorders such as Von Willebrands disease (VWD) present with varying bleeding tendencies in different individuals. There have been several attempts to identify the determinants for this varying severity of the haemorrhagic manifestations, especially in those with milder forms or type 1 VWD. Genetic mutations have been noted in persons with haemophilia to be contributing to a milder bleeding phenotype. This report describes the clinical implications of a similar mixed haemorrhagic-thrombotic genotype.

References

Nov 2, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·M GrünewaldM Griesshammer
Apr 17, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·K J PasiI R Peake
Jul 23, 2004·Thrombosis and Haemostasis·Karin van DijkH Marijke van den Berg
Dec 1, 2004·Circulation·Andrew C ParkerWilliam P Fay
Dec 20, 2005·Journal of Thrombosis and Haemostasis : JTH·A SchlachtermanV R Arruda
May 9, 2006·American Journal of Hematology·Massimo FranchiniGiuseppe Lippi
Apr 12, 2008·Haematologica·Armando TripodiPier Mannuccio Mannucci
Aug 8, 2009·British Journal of Haematology·Armando TripodiPier M Mannucci
Aug 25, 2009·Obstetrics and Gynecology·Andra H JamesWilliam L Nichols
Dec 5, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Firdos AhmadRenu Saxena

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.