Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study

The American Journal of Cardiology
Joel A SimonRonald M Krauss

Abstract

Although statins are effective lipid-lowering agents, the phenotypic and demographic predictors of such lowering have been less well examined. We enrolled 944 African-American and white men and women who completed an open-label, 6-week pharmacogenetics trial of 40 mg of simvastatin. The phenotypic and demographic variables were examined as predictors of the change in lipids and lipoproteins using linear regression analysis. On average, treatment with simvastatin lowered low-density lipoprotein (LDL) cholesterol by 54 mg/dl and increased high-density lipoprotein (HDL) cholesterol by 2 mg/dl. Compared with African-Americans, whites had a 3-mg/dl greater LDL reduction and a 1-mg/dl higher HDL elevation, independent of other variables, including baseline lipoprotein levels (p <0.01). Multivariate analyses revealed moderate subgroup differences, with older participants having a larger decrease in LDL cholesterol and apolipoprotein B levels compared with younger participants (p <0.001), women having larger increases in HDL than men (p <0.01), nonsmokers having larger decreases in LDL and triglyceride levels compared with smokers (p <0.05), those with hypertension having smaller decreases in apolipoprotein B than those without hyperte...Continue Reading

Associated Clinical Trials

Citations

May 22, 2013·Current Cardiology Reports·Peter Weeke, Dan M Roden
Mar 12, 2011·Journal of Cardiovascular Translational Research·Zhu ChenAmy M Flattery
Aug 16, 2011·Nature Genetics·Gregory M CooperEvan E Eichler
May 2, 2012·The Pharmacogenomics Journal·F H van der BaanJ W Jukema
Sep 5, 2013·Human Molecular Genetics·Chi-Yi YuMarisa W Medina
Nov 3, 2010·Pharmacogenetics and Genomics·Bas J M PetersAnke-Hilse Maitland-van der Zee
Dec 30, 2009·Pharmacological Reviews·Marleen WelshM Eileen Dolan
Jan 25, 2011·Gut·Talin HarituniansKent D Taylor
Dec 20, 2011·Journal of Medical Genetics·Mark O GoodarziMargrit Urbanek
Apr 24, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Lara M MangraviteRonald M Krauss
Dec 25, 2009·Circulation. Cardiovascular Genetics·Deepak VooraGeoffrey S Ginsburg
Sep 17, 2011·Circulation Research·Dan M RodenRussell A Wilke
Nov 29, 2011·Nutrition Journal·Thomas M S WoleverRuedi Duss
Dec 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Susan G LakoskiHelen H Hobbs
Nov 22, 2011·PLoS Genetics·Santhosh GirirajanEvan E Eichler
Nov 21, 2012·PLoS Genetics·Marisa W MedinaRonald M Krauss
Oct 25, 2011·PloS One·Rima Kaddurah-DaoukRonald M Krauss
Dec 20, 2011·Pharmacogenomics·Heather E Wheeler, M Eileen Dolan
Dec 3, 2013·Current Atherosclerosis Reports·Jaideep PatelH Robert Superko
Feb 11, 2014·Pharmacology & Therapeutics·Peter J MeikleBronwyn A Kingwell
Jul 6, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Z Reiner
May 7, 2010·Metabolomics : Official Journal of the Metabolomic Society·Rima Kaddurah-DaoukRonald M Krauss
Sep 4, 2015·International Journal of Molecular Sciences·Yalena PradoLuis A Salazar
Apr 11, 2015·International Journal of Molecular Sciences·Jenny LagosLuis A Salazar
Jun 4, 2014·Current Medical Research and Opinion·Gregory HessKaren Chung
Oct 24, 2015·Fertility and Sterility·Aline KetefianMark O Goodarzi
Mar 7, 2012·The Medical Clinics of North America·H Robert SuperkoYonghong Li
Jun 18, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M-J Shin, O Y Kim
Dec 17, 2009·Trends in Cardiovascular Medicine·Marisa Wong Medina, Ronald M Krauss

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