Phenotypic variability of retinocytomas: preregression and postregression growth patterns

The British Journal of Ophthalmology
Hana AbouzeidFrancis L Munier

Abstract

To describe the incidence of retinocytomas, their variability at presentation and their growth patterns both before and after regression. Medical notes of the 525 patients of the Jules-Gonin Eye Hospital Retinoblastoma Clinic between 1964 and 2008 were reviewed and the charts of 36 patients with retinocytomas and/or phthisis bulbi were selected. The proportion of patients with retinocytomas and/or phthisis bulbi was 3.2%. The mean age at diagnosis was 28.7 ± 17 years. Five tumours presented a cystic pattern (5.8%). Evidence of aggressive exophytic disease prior to spontaneous regression was documented in two eyes, and of invasive endophytic disease (regressed vitreous seeding or internal limiting membrane disruption) in three eyes. Twenty patients were followed with a mean follow-up of 44 ± 60 months. Tumour growth was observed in 16% cases, benign cystic enlargement in 4% and malignant transformation in 12%. This large study of retinocytomas substantially expands the published features of retinocytoma by describing the cystic nature of some retinocytomas as well as clinical characteristics of the endophytic and exophytic preregression growth patterns. The authors report two different patterns of reactivation: benign cystic enl...Continue Reading

Citations

Jun 19, 2016·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Hayyam Kiratli, Irem Koç
Jul 6, 2016·Archivos de la Sociedad Española de Oftalmología·V M Asensio-Sánchez, L Díaz-Cabanas
Oct 18, 2016·Retina·Kemal TekinSandeep Randhawa
Oct 19, 2017·Der Pathologe·K A MetzC H D Le Guin
Nov 6, 2018·Ophthalmic Surgery, Lasers & Imaging Retina·Manuel Paez-EscamillaJ William Harbour
Jan 31, 2020·Molecular Genetics & Genomic Medicine·Shijing WuRuifang Sui
May 30, 2021·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Carol L ShieldsJerry A Shields

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