Phenotypic variants of meningococci and their potential in phagocytic interactions: the influence of opacity proteins, pili, PilC and surface sialic acids

Microbial Pathogenesis
G McNeil, M Virji

Abstract

In previous studies we have examined the roles of meningococcal surface structures (capsule, lipopolysaccharides, pili and opacity proteins: Opa and Opc) in bacterial interactions with human epithelial, endothelial and mononuclear phagocytic cells. In the current investigations, using defined derivatives of a serogroup A strain C751 and a serogroup B strain MC58, we studied the roles of these structures with human polymorphonuclear phagocytes (PMN). In addition, we examined the potential influence of the pilus-associated protein, PilC, previously known to affect epithelial cell interactions. The data show, that, as with monocytes, opacity proteins affect bacterial interactions with PMN and require surface sialic acids (on capsule and LPS) to be down-modulated in order to function. Also, in contrast to their role in human epithelial and endothelial adherence, neither pili nor PilC expression had any effect on phagocytic cell interactions with respect to induction of chemiluminescence as well as phagocytic killing. Examination of the relative influence of Opa and Opc indicated that Opa proteins are more effective than Opc in PMN interactions whereas the reverse was the case with monocytes. These results suggest that Opa and Opc m...Continue Reading

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Citations

Jun 30, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Smith
Jul 20, 2004·Clinical Microbiology Reviews·Marjan W van der Woude, Andreas J Bäumler
Mar 25, 2004·Infection and Immunity·Leah D FletcherGary W Zlotnick
May 30, 2008·Journal of Clinical Microbiology·Martin J CallaghanAndrew J Pollard
Jan 6, 2011·FEMS Microbiology Reviews·Manish SadaranganiScott D Gray-Owen
Jan 1, 2013·Biology·Miao-Chiu Hung, Myron Christodoulides
Jul 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steve J WebsterDavid H Dockrell
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michele M EstabrookGary A Jarvis
Feb 13, 2001·Vaccine·A J Pollard, C Frasch

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