PMID: 8970967Dec 1, 1996Paper

Phenotypical characterization of lymphocytes infiltrating regressing papillomas

Journal of Virology
G KnowlesM S Campo

Abstract

Papillomavirus-induced lesions often regress spontaneously in both humans and animals. Papilloma regression is deemed to be due to a cell-mediated immune response, the nature of which is still ill defined, and is accompanied by immune cell infiltrates. To gain further information on the nature and role of the immune cells present in regressing papillomas, we have analyzed biopsies of papillomas induced in the soft palate of cattle by bovine papillomavirus type 4 (BPV-4) and have phenotypically characterized and quantified the lymphocytes present in these lesions. Eleven papilloma biopsies and seven biopsies of noninfected palate were analyzed for the presence of activated CD4+, CD8+, and gamma delta(WC1+) lymphocytes. We found large numbers of lymphocytes in the subepithelial derma of papillomas but not in normal palate tissue; these cellular masses consisted predominantly of CD4+ lymphocytes, with only a few CD8+ and gamma delta(WC1+) lymphocytes, generally positioned at the periphery of these masses. All three subtypes of lymphocytes were found interdigitated with the cells of the basal layer both in papillomas and in normal palate tissue, but while basal layer CD8+ and gamma delta(WC1+) T cells were detected with similar fre...Continue Reading

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Citations

May 16, 2008·Veterinary Research·Giuseppe Borzacchiello, Franco Roperto
Apr 11, 2007·The Annals of Otology, Rhinology, and Laryngology·Yoram SternKarl Segal
Mar 29, 2014·BioMed Research International·Maria Isabel CarvalhoFelisbina L Queiroga
Mar 1, 2003·Veterinary and Comparative Oncology·M S Campo
Nov 13, 2009·Journal of Virology·M Saveria Campo, Richard B S Roden
Oct 18, 2008·Veterinary Dermatology·Lubna Nasir, M Saveria Campo
Mar 26, 2014·Transboundary and Emerging Diseases·F BocanetiG Borzacchiello
Sep 28, 2004·The Journal of General Virology·E H AraibiM S Campo
Oct 12, 2018·Acta Veterinaria Scandinavica·Joanna Katarzyna BujakKinga Majchrzak
Oct 22, 2020·Veterinary and Comparative Oncology·Onur Kaynarcalidan, Tuba Çiğdem Oğuzoğlu
Sep 26, 2002·Virus Research·Philippa M O'Brien, M Saveria Campo

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