Phenotypical heterogeneity of CD4+CD8+ double-positive chronic T lymphoid leukemia

Leukemia
M MizukiT Kitani

Abstract

Chronic T lymphoid leukemias are defined as leukemias of post-thymic T cells. The CD4+CD8+ double-positive (DP) phenotype is seen in a few cases. Since DP generally occurs in thymic T cells, whether the DP T leukemia cells represent thymic or peripheral T cells has been a matter of controversy. To address this issue, we studied phenotypical features in eight cases of DP T cell leukemia. Thymic DP T cells and peripheral CD8+ T cells have CD8 of alphabeta subunit, while CD8alphaalpha is induced in CD4+ T cells on activation with IL-4. We found that two patients with DP T large granular lymphocyte leukemia (LGLL) showed dim expression of CD8alphaalpha, identical to the phenotype on IL-4-activated DP-T cells. The leukemic cells of these patients expressed IL-4 mRNA and produced high levels of IL-4. These findings suggest that they may be derived from peripheral CD4+ T cells. Three patients with adult T cell leukemia/lymphoma (ATLL) showed CD8alphaalpha, suggestive of an activated peripheral T cell origin. One case expressed CD8alphaalpha dim and IL-4 mRNA, while the other two cases expressed no IL-4 mRNA and showed CD8alphaalpha bright phenotype, features not found in normal T cell populations. Three patients with T-prolymphocytic ...Continue Reading

Citations

Feb 1, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Astrid M BedoyaGloria I Sanchez
Sep 3, 2011·PLoS Neglected Tropical Diseases·Nicolas A GiraldoJohn M González
Apr 6, 2004·Leukemia & Lymphoma·Keiko AndoKazuma Ohyashiki
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Helen H ChunRichard A Gatti
Aug 11, 2015·The American Journal of Dermatopathology·Vishwas ParekhKristopher McKay
Apr 20, 2007·Digestive Diseases and Sciences·Cem CengizSevinc Yilmaz
Apr 12, 2019·Biomedical Reports·Adriane Penczek, Timo Burster

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