Phenotyping asthma in the elderly: allergic sensitization profile and upper airways comorbidity in patients older than 65 years

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Carlo LombardiELSA Study Group

Abstract

Data about allergic rhinitis in elderly patients with asthma are lacking. To investigate the presence of rhinitis and the role of sensitization of airborne allergens in elderly patients with asthma. This was a multicenter cross-sectional study involving subjects at least 65 years old with asthma. Demographic features, comorbidities, and the presence of allergic respiratory disease were retrieved through interview. Skin prick tests for common allergens were performed. Associations of demographic and clinical features were evaluated in relation to asthma control and forced expiratory volume in the first second less than 80% in the total population and in the subgroup with features resembling chronic obstructive pulmonary disease. Of 368 elderly subjects with asthma, 101 had features resembling chronic obstructive pulmonary disease. Rhinitis was present in 59.0% of subjects (allergic rhinitis in 47.6%), with an age of onset significantly different from that of asthma (49 ± 18 vs 57 ± 18 years). At least 1 sensitization was observed in 52.4% of subjects, more frequently for house dust mite (HDM; 31.8%). The prevalence of poorly and partially controlled asthma was higher in patients sensitized to airborne allergens (odds ratio 1.64,...Continue Reading

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Citations

Jun 16, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Giorgio CiprandiFabio L M Ricciardolo
Oct 23, 2016·Drugs & Aging·Hoang Kim Tu TrinhHae-Sim Park
Feb 9, 2017·Clinical and Molecular Allergy : CMA·Maria Teresa VenturaGiorgio Walter Canonica
May 20, 2017·Current Opinion in Allergy and Clinical Immunology·Gyu-Young HurHae-Sim Park
Dec 20, 2017·Current Opinion in Allergy and Clinical Immunology·Jeffrey M ChamblissJulia W Tripple
Aug 2, 2019·The American Journal of Chinese Medicine·Chia-Chen HsiehJen-Chieh Tsai

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