Phenotyping Heart Failure According to the Longitudinal Ejection Fraction Change: Myocardial Strain, Predictors, and Outcomes.

Journal of the American Heart Association
Jin Joo ParkGoo-Yeong Cho

Abstract

Background Many patients with heart failure (HF) experience changes in left ventricular ejection fraction (LVEF) during follow-up. We sought to evaluate the predictors and outcomes of different HF phenotypes according to longitudinal changes in EF. Methods and Results A total of 2104 patients with acute HF underwent echocardiography at baseline and follow-up. Global longitudinal strain was measured at index admission. HF phenotypes were defined as persistent HF with reduced EF (persistent HFrEF, LVEF ≤40% at baseline and follow-up), heart failure with improved ejection fraction (LVEF≤40% at baseline and improved to >40% at follow-up), heart failure with declined ejection fraction (LVEF>40% at baseline and declined to ≤40% at follow up), and persistent HF with preserved EF (persistent HFpEF, LVEF>40% at baseline and follow-up). Overall, 1130 patients had HFrEF at baseline; during follow-up, 54.2% and 46.8% had persistent HFrEF and heart failure with improved ejection fraction, respectively. Among 975 patients with HFpEF at baseline, 89.5% and 10.5% had persistent HFpEF and heart failure with declined ejection fraction at follow-up, respectively. The 5-year all-cause mortality rates were 43.1%, 33.1%, 24%, and 17% for heart failu...Continue Reading

References

Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
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Nov 5, 2013·Journal of the American College of Cardiology·Elisabeth Kraigher-KrainerUNKNOWN PARAMOUNT Investigators
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt
Jan 27, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Attila KovácsTamás Radovits
Sep 1, 2015·Heart·Si-Hyuck KangUNKNOWN KorHF Registry
Apr 4, 2017·European Journal of Heart Failure·Kanako TsujiUNKNOWN CHART-2 Investigators
Apr 8, 2017·European Journal of Heart Failure·Josep LupónAntoni Bayés-Genís
Sep 29, 2017·Korean Circulation Journal·Min-Seok KimDong-Ju Choi
May 5, 2018·Journal of the American College of Cardiology·Jin Joo ParkGoo-Yeong Cho
Jan 25, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Masayoshi YamamotoMasaki Ieda
Feb 28, 2019·JAMA Cardiology·Thomas H MarwickJames D Thomas
Mar 9, 2019·Journal of the American Heart Association·Chan Soon ParkDong-Ju Choi
Jul 4, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jin Joo ParkDong-Ju Choi

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Citations

Jan 13, 2021·Journal of Clinical Medicine·Eleni-Evangelia KoufouAndreas P Kalogeropoulos
Apr 15, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Yuta ToriiMasataka Sata

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Clinical Trials Mentioned

NCT03513653

Software Mentioned

R
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