PMID: 6540237Apr 1, 1984Paper

Phenotyping of canine lymphoma with monoclonal antibodies directed at cell surface antigens: classification, morphology, clinical presentation and response to chemotherapy

Hematological Oncology
F R AppelbaumJ C Wulff

Abstract

Forty cases of naturally occurring canine lymphoma were studied using a panel of murine monoclonal antibodies which identify defined subsets of normal canine lymphocytes. The distribution of phenotypes was similar to that which is seen in man in that the majority (78 per cent) of canine lymphomas were of B-cell origin but a definite minority were phenotypically of T-cell (10 per cent) or non-B, non-T-cell (12 per cent) origin. The expression of Ia-like antigens was restricted to B-cell neoplasms. Within each histologic subgroup of canine lymphomas there was considerable heterogeneity of cell surface marker expression. Immunophenotype appeared to correlate with clinical presentation. Finally, the reactivity of lymphoma cells with murine monoclonal antibody DLy-6, an antibody which appears to react with a differentiation antigen on canine B and T cells, strongly predicted the outcome of initial induction chemotherapy in that all ten evaluable dogs with DLy-6-tumors achieved complete responses to initial chemotherapy while only four of 11 dogs with DLy-6+ tumors responded completely.

References

Sep 1, 1977·Journal of the National Cancer Institute·D Onions
Jan 1, 1976·Journal of the National Cancer Institute·C A HolmbergB I Osburn
Jan 1, 1969·Acta Haematologica·A Polliack, E Rosenmann
Jan 1, 1981·Leukemia Research·M F GreavesG Goldstein
Jan 1, 1982·Immunogenetics·H J DeegR Storb
Jun 1, 1982·Transplantation·J C WulffR Storb

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Citations

Jan 1, 1991·Veterinary Clinical Pathology·Nemi C. JainJoseph G. Zinkl
Jun 21, 2002·Veterinary Clinical Pathology·Carol B. GrindemEdward B. Breitschwerdt
Oct 17, 1998·Journal of Veterinary Internal Medicine·M D LucroyB R Madewell
Aug 4, 2009·Journal of Veterinary Internal Medicine·E M BrodskyG S Post
Apr 4, 2013·Irish Veterinary Journal·Stratos PapakonstantinouPeter J O'Brien
Jan 13, 2005·Veterinary Ophthalmology·Marta VascellariFranco Mutinelli
Mar 10, 2016·The Veterinary Quarterly·M Zandvliet
Mar 6, 2007·The Veterinary Clinics of North America. Small Animal Practice·Anne C Avery, Paul R Avery
Apr 10, 2007·Journal of Comparative Pathology·A Guija de ArespacochagaH Weissenböck
Sep 1, 2004·Veterinary and Comparative Oncology·D M LurieB R Madewell
Jun 21, 2005·Veterinary Immunology and Immunopathology·M J WilkersonA Avery
Sep 1, 1996·The Veterinary Clinics of North America. Small Animal Practice·C B Grindem
Jul 1, 1989·The Veterinary Clinics of North America. Small Animal Practice·J N Mills
Jul 1, 1990·The Veterinary Clinics of North America. Small Animal Practice·R C Rosenthal
Aug 24, 2001·The Journal of Small Animal Practice·J M DobsonB D Tom
Jul 28, 2016·Veterinary and Comparative Oncology·A RupleP S Morley
Sep 17, 2016·The Veterinary Record·Antony S Moore
May 20, 2017·Veterinary and Comparative Oncology·D SayagF Ponce
Aug 1, 1990·Cancer·P G GreenleeP H Lieberman
Aug 16, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·F PonceC Fournel-Fleury
Sep 1, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Mahmut SözmenMarco Caldin
Jul 27, 1999·Veterinary Pathology·M KiupelD Bostock
Jul 10, 2002·Veterinary Pathology·C Fournel-FleuryJ P Magnol
Mar 1, 1996·Veterinary Pathology·M CaniattiP F Moore
Jul 31, 1998·Veterinary Pathology·L C Kelley, E A Mahaffey
Nov 15, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·E KaldrymidouT Tsangaris
Jul 18, 2017·Veterinary Ophthalmology·Matthew R LanzaAmy C Durham
Jun 1, 2002·Veterinary Clinical Pathology·Douglas J Weiss
Jul 23, 2019·Veterinary Ophthalmology·Ayla R MuscianoAmy C Durham
Nov 23, 2020·Veterinary and Comparative Oncology·Nicole WeidnerAdronie Verbrugghe

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