Phenotyping of Chronic Obstructive Pulmonary Disease Based on the Integration of Metabolomes and Clinical Characteristics

International Journal of Molecular Sciences
Kalle KilkAlan Altraja

Abstract

Apart from the refined management-oriented clinical stratification of chronic obstructive pulmonary disease (COPD), the molecular pathologies behind this highly prevalent disease have remained obscure. The aim of this study was the characterization of patients with COPD, based on the metabolomic profiling of peripheral blood and exhaled breath condensate (EBC) within the context of defined clinical and demographic variables. Mass-spectrometry-based targeted analysis of serum metabolites (mainly amino acids and lipid species), untargeted profiles of serum and EBC of patients with COPD of different clinical characteristics (n = 25) and control individuals (n = 21) were performed. From the combined clinical/demographic and metabolomics data, associations between clinical/demographic and metabolic parameters were searched and a de novo phenotyping for COPD was attempted. Adjoining the clinical parameters, sphingomyelins were the best to differentiate COPD patients from controls. Unsaturated fatty acid-containing lipids, ornithine metabolism and plasma protein composition-associated signals from the untargeted analysis differentiated the Global Initiative for COPD (GOLD) categories. Hierarchical clustering did not reveal a clinical-...Continue Reading

Associated Clinical Trials

Aug 2, 2019·LuQian Zhou

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Citations

Mar 26, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shabarinath NambiarYuben Moodley
Nov 30, 2019·Metabolites·Dimitris TsoukalasAristides Tsatsakis
Mar 27, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Juntuo ZhouYuxin Yin
Oct 3, 2021·Metabolomics : Official Journal of the Metabolomic Society·Priyanka ChoudhuryKoel Chaudhury
Oct 16, 2021·Thorax·Rachel S KellyJessica A Lasky-Su

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Methods Mentioned

BETA
PCA
NMR

Software Mentioned

sPLSDA mixOmics
Visual Basic
clusterSim
fpc
R
clValid
sPLSDA

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