Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies

British Medical Bulletin
Nimeshi JayakodyDavid Coggon

Abstract

Phenoxy herbicides have been used widely in agriculture, forestry, parks and domestic gardens. Early studies linked them with soft-tissue sarcoma (STS) and non-Hodgkin lymphoma (NHL), but when last reviewed by the International Agency for Research on Cancer in 1986, the evidence for human carcinogenicity was limited. We searched Medline and Embase, looking for cohort or case-control studies that provided data on risk of STS and/or NHL in relation to phenoxy herbicides, and checked the reference lists of relevant publications for papers that had been missed. The extensive evidence is not entirely consistent, and a hazard of STS or NHL cannot firmly be ruled out. However, if there is a hazard, then absolute risks must be small. Extended follow-up of previously assembled cohorts may be the most efficient way of further reducing uncertainties.

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Citations

Mar 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandra BiancolilloAngelo Antonio D'Archivio
Jan 27, 2021·International Archives of Occupational and Environmental Health·Carol J Burns, Daland R Juberg
Feb 20, 2021·Environmental Research·Michael K OdutolaClaire M Vajdic
Dec 7, 2018·Chemical Reviews·Teresa L MakoMindy Levine
Nov 16, 2021·The Journal of Bone and Joint Surgery. American Volume·Jacob Bickels, Martin M Malawer

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